POEM of the Week Archive
Episode 695: Monoclonal antibodies for Alzheimer disease: A lack of clinically meaningful benefits, plus significant harms
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Monoclonal antibodies for Alzheimer disease: A lack of clinically meaningful benefits, plus significant harms '
Download Episode 695 (mp3, 10.2MB)
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Episode 694: Patient reminders combined with clinician audit and feedback increases human papillomavirus vaccine uptake
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Patient reminders combined with clinician audit and feedback increases human papillomavirus vaccine uptake '
Download Episode 694 (mp3, 5.4MB)
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Episode 693: Canadian Thoracic Society guidelines for pharmacotherapy of stable chronic obstructive pulmonary disease
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Canadian Thoracic Society guidelines for pharmacotherapy of stable chronic obstructive pulmonary disease '
Download Episode 693 (mp3, 6.1MB)
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Episode 692: Scottish screening: 0 cases of invasive cervical cancer in women who received at least 1 dose of bivalent HPV vaccine at 12 or 13 years of age
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Scottish screening: 0 cases of invasive cervical cancer in women who received at least 1 dose of bivalent HPV vaccine at 12 or 13 years of age '
Download Episode 692 (mp3, 6.5MB)
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Episode 691: High-dose recombinant flu vaccine: NNT = 3000 to prevent one more infection, no impact on hospitalization
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' High-dose recombinant flu vaccine: NNT = 3000 to prevent one more infection, no impact on hospitalization '
Download Episode 691 (mp3, 5.2MB)
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Episode 690: Delivery of bad news via phone = in-person delivery
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Delivery of bad news via phone = in-person delivery '
Download Episode 690 (mp3, 6.4MB)
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Episode 689: PCI is better than placebo for stable angina in patients who do not take anti-anginal medications (ORBITA-2)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' PCI is better than placebo for stable angina in patients who do not take anti-anginal medications (ORBITA-2) '
Download Episode 689 (mp3, 5.5MB)
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Episode 688: Wait-and-watch is an option for patients with symptomatic but uncomplicated gallstones
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Wait-and-watch is an option for patients with symptomatic but uncomplicated gallstones '
Download Episode 688 (mp3, 4.9MB)
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Episode 687: Brexpiprazole improves agitation scores in adults with Alzheimer disease who have agitated behaviors
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Brexpiprazole improves agitation scores in adults with Alzheimer disease who have agitated behaviors '
Download Episode 687 (mp3, 4.2MB)
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Episode 686: ACC/AHA guideline for the management of patients with chronic coronary disease
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' ACC/AHA guideline for the management of patients with chronic coronary disease '
Download Episode 686 (mp3, 6MB)
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Episode 685: Positive, rather than negative, messaging of weight loss might motivate patients to try to lose weight
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Positive, rather than negative, messaging of weight loss might motivate patients to try to lose weight '
Download Episode 685 (mp3, 4.2MB)
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Episode 684: Network meta-analysis: Limited data show that high-dose aspirin decreases incidence of colorectal cancer
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Network meta-analysis: Limited data show that high-dose aspirin decreases incidence of colorectal cancer '
Download Episode 684 (mp3, 5.8MB)
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Episode 683: Cognitive behavioral therapy effective for patients with fatigue associated with long COVID
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Cognitive behavioral therapy effective for patients with fatigue associated with long COVID '
Download Episode 683 (mp3, 6.1MB)
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Episode 682: The risk of breast cancer overdiagnosis is high for older women
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' The risk of breast cancer overdiagnosis is high for older women '
Download Episode 682 (mp3, 6.1MB)
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Episode 681: Esketamine is superior to quetiapine for remission of treatment-resistant depression (ESCAPE-TRD)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Esketamine is superior to quetiapine for remission of treatment-resistant depression (ESCAPE-TRD) '
Download Episode 681 (mp3, 6.3MB)
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Episode 680: Wrong blood pressure cuff size can falsely increase or decrease readings
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Wrong blood pressure cuff size can falsely increase or decrease readings '
Download Episode 680 (mp3, 4.7MB)
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Episode 679: Early BP treatment for acute ischemic stroke has no impact on mortality or functional outcomes (CATIS-2)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Early BP treatment for acute ischemic stroke has no impact on mortality or functional outcomes (CATIS-2) '
Download Episode 679 (mp3, 6.8MB)
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Episode 678: Acetaminophen and ketorolac are more effective than morphine in alleviating pain in adults with renal colic
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Acetaminophen and ketorolac are more effective than morphine in alleviating pain in adults with renal colic '
Download Episode 678 (mp3, 4.6MB)
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Episode 677: Terbinafine 250 mg once daily — 12 weeks on, 12 weeks off, 4 weeks on — is preferred for onychomycosis in adults
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Terbinafine 250 mg once daily — 12 weeks on, 12 weeks off, 4 weeks on — is preferred for onychomycosis in adults '
Download Episode 677 (mp3, 7.1MB)
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Episode 676: Nearly zero risk of sexually transmitting HIV when viral loads are less than 1000 copies per mL
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Nearly zero risk of sexually transmitting HIV when viral loads are less than 1000 copies per mL '
Download Episode 676 (mp3, 5.2MB)
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Episode 675: Overweight/obese adults with symptomatic COVID-19 treated with metformin are less likely to develop long COVID (COVID-OUT)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Overweight/obese adults with symptomatic COVID-19 treated with metformin are less likely to develop long COVID (COVID-OUT) '
Download Episode 675 (mp3, 5.7MB)
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Episode 674: Amoxicillin is no more likely to cause rash than any other antibiotic in patients with mononucleosis
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Amoxicillin is no more likely to cause rash than any other antibiotic in patients with mononucleosis '
Download Episode 674 (mp3, 5.5MB)
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Episode 673: Once-and-done screening colonoscopy has higher rates of adherence than yearly fecal-based blood testing
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Once-and-done screening colonoscopy has higher rates of adherence than yearly fecal-based blood testing '
Download Episode 673 (mp3, 6.2MB)
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Episode 672: Early treatment of gestational diabetes is modestly beneficial for neonatal and maternal outcomes
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Early treatment of gestational diabetes is modestly beneficial for neonatal and maternal outcomes '
Download Episode 672 (mp3, 5.6MB)
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Episode 671: Most people tolerate bedtime thiazide diuretics
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Most people tolerate bedtime thiazide diuretics '
Download Episode 671 (mp3, 5.8MB)
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Episode 670: Cholesterol-reducer evolocumab associated with a nonsignificant increase in cardiovascular mortality (FOURIER)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Cholesterol-reducer evolocumab associated with a nonsignificant increase in cardiovascular mortality (FOURIER) '
Download Episode 670 (mp3, 5.5MB)
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Episode 669: Mifepristone effective and safe for the treatment of adenomyosis with pain symptoms
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Mifepristone effective and safe for the treatment of adenomyosis with pain symptoms '
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Episode 668: Direct oral anticoagulants are noninferior to low-molecular-weight heparin to prevent recurrent VTE in adults with cancer
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Direct oral anticoagulants are noninferior to low-molecular-weight heparin to prevent recurrent VTE in adults with cancer '
Download Episode 668 (mp3, 5.8MB)
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Episode 667: Early return to activity improves symptoms in children with concussion
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Early return to activity improves symptoms in children with concussion '
Download Episode 667 (mp3, 4.1MB)
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Episode 666: Tailored exercise program improves function and reduces pain due to knee osteoarthritis
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Tailored exercise program improves function and reduces pain due to knee osteoarthritis '
Download Episode 666 (mp3, 5.9MB)
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Episode 665: A daily multivitamin has modest impact on memory in older adults (COSMOS-WEB)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' A daily multivitamin has modest impact on memory in older adults (COSMOS-WEB) '
Download Episode 665 (mp3, 6.5MB)
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Episode 664: Older treatments for type 2 diabetes do not affect patient-oriented outcomes
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Older treatments for type 2 diabetes do not affect patient-oriented outcomes '
Download Episode 664 (mp3, 5MB)
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Episode 663: Intravenous hydrocortisone reduces all-cause mortality in severe community-acquired pneumonia (CAPE COD)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Intravenous hydrocortisone reduces all-cause mortality in severe community-acquired pneumonia (CAPE COD) '
Download Episode 663 (mp3, 5.9MB)
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Episode 662: Postexposure prophylaxis with doxycycline in men who have sex with men and transgender women with or at risk of HIV reduces STI risk (NNT = 5)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Postexposure prophylaxis with doxycycline in men who have sex with men and transgender women with or at risk of HIV reduces STI risk (NNT = 5) '
Download Episode 662 (mp3, 7.1MB)
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Episode 661: Bivalent respiratory syncytial virus (RSV) vaccine given to mothers reduces total and severe RSV infections in infants
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Bivalent respiratory syncytial virus (RSV) vaccine given to mothers reduces total and severe RSV infections in infants '
Download Episode 661 (mp3, 5.2MB)
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Episode 660: Bempedoic acid 180 mg reduces risk of nonfatal myocardial infarction and revascularization; NNT = 42 in primary prevention group (CLEAR)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Bempedoic acid 180 mg reduces risk of nonfatal myocardial infarction and revascularization; NNT = 42 in primary prevention group (CLEAR) '
Download Episode 660 (mp3, 8.9MB)
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Episode 659: Discectomy for sciatica provides short-term relief for leg pain
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Discectomy for sciatica provides short-term relief for leg pain '
Download Episode 659 (mp3, 7.1MB)
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Episode 658: Active surveillance reduces the need for surgery, with no change in mortality, at the price of a small increase of metastatic disease (ProtecT)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Active surveillance reduces the need for surgery, with no change in mortality, at the price of a small increase of metastatic disease (ProtecT) '
Download Episode 658 (mp3, 6.8MB)
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Episode 657: Early invasive strategy does not reduce mortality for moderate to severe ischemic heart disease after 5.8 years (ISCHEMIA-EXTEND)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Early invasive strategy does not reduce mortality for moderate to severe ischemic heart disease after 5.8 years (ISCHEMIA-EXTEND) '
Download Episode 657 (mp3, 6.1MB)
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Episode 656: Among antidepressants, only serotonin-norepinephrine reuptake inhibitors are effective for pain
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Among antidepressants, only serotonin-norepinephrine reuptake inhibitors are effective for pain '
Download Episode 656 (mp3, 4.6MB)
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Episode 655: Low FODMAPS diet is better than an oral spasmolytic for irritable bowel syndrome (NNT = 7 – 9)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Low FODMAPS diet is better than an oral spasmolytic for irritable bowel syndrome (NNT = 7 – 9) '
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Episode 655: Low FODMAPS diet is better than an oral spasmolytic for irritable bowel syndrome (NNT = 7 – 9)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Low FODMAPS diet is better than an oral spasmolytic for irritable bowel syndrome (NNT = 7 – 9) '
Download Episode 655 (mp3, 6MB)
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Episode 654: Letrozole more efficacious than clomiphene for infertility treatment among individuals with polycystic ovarian syndrome
Dr. Ebell and Dr. Wilkes discuss the POEM titled 'Letrozole more efficacious than clomiphene for infertility treatment among individuals with polycystic ovarian syndrome '
Download Episode 654 (mp3, 4.1MB)
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Episode 653: Brief behavioral therapy improves sleep in older adults with chronic insomnia
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Brief behavioral therapy diminishes insomnia in the elderly '
Download Episode 653 (mp3, 5.4MB)
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Episode 652: Mindfulness-based stress reduction is noninferior to escitalopram for adults with anxiety disorder
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Mindfulness-based stress reduction is noninferior to escitalopram for adults with anxiety disorder '
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Episode 651: No benefit with torsemide over furosemide for posthospitalization treatment of heart failure (TRANSFORM-HF)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' No benefit with torsemide over furosemide for posthospitalization treatment of heart failure (TRANSFORM-HF) '
Download Episode 651 (mp3, 5MB)
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Episode 650: Lecanemab does not significantly improve cognition in early Alzheimer's disease, is expensive, and causes brain edema and hemorrhage in some patients
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Lecanemab does not significantly improve cognition in early Alzheimer's disease, is expensive, and causes brain edema and hemorrhage in some patients '
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Episode 649: Chlorthalidone no better than hydrochlorothiazide for hypertension
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Chlorthalidone no better than hydrochlorothiazide for hypertension '
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Episode 648: Twice-daily low-dose aspirin is similar to enoxaparin for thromboprophylaxis after inpatient treatment for fracture (PREVENT CLOT)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Twice-daily low-dose aspirin is similar to enoxaparin for thromboprophylaxis after inpatient treatment for fracture (PREVENT CLOT) '
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Episode 647: Tell patients their new knee won't wear out sooner with hard use
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Tell patients their new knee won't wear out sooner with hard use '
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Episode 646: Majority of CIN2 regress in women aged 25 to 30 years
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Majority of CIN2 regress in women aged 25 to 30 years '
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Episode 645: Morning and bedtime dosing of antihypertensives have similar rates of major cardiovascular events (TIME)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Morning and bedtime dosing of antihypertensives have similar rates of major cardiovascular events (TIME) '
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Episode 644: Use of ACEIs and ARBs in advanced chronic kidney disease does not worsen, and may improve, renal outcomes
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Use of ACEIs and ARBs in advanced chronic kidney disease does not worsen, and may improve, renal outcomes '
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Episode 643: Invitation to a single colonoscopy has only modest impact on colorectal cancer incidence (NordICC)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Invitation to a single colonoscopy has only modest impact on colorectal cancer incidence (NordICC) '
Download Episode 643 (mp3, 6.7MB)
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Episode 642: Tocilizumab beneficial for adults with persistent polymyalgia rheumatica symptoms who receive steroid therapy
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Tocilizumab beneficial for adults with persistent polymyalgia rheumatica symptoms who receive steroid therapy '
Download Episode 642 (mp3, 4.9MB)
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Episode 641: Improved decongestion with the addition of acetazolamide to intravenous loop diuretics for acute heart failure
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Improved decongestion with the addition of acetazolamide to intravenous loop diuretics for acute heart failure '
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Episode 640: Rebound symptoms common with COVID-19 even after placebo treatment
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Rebound symptoms common with COVID-19 even after placebo treatment '
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Episode 639: Limited evidence for meds, music, and massage to treat anxiety in residents of long-term care facilities
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Limited evidence for meds, music, and massage to treat anxiety in residents of long-term care facilities '
Download Episode 639 (mp3, 5.9MB)
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Episode 638: Percutaneous coronary intervention does not improve outcomes for patients with ischemic heart disease and LVEF of less than 35%
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Percutaneous coronary intervention does not improve outcomes for patients with ischemic heart disease and LVEF of less than 35% '
Download Episode 638 (mp3, 5.5MB)
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Episode 637: Nonpharmacologic approaches can improve fibromyalgia symptoms
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Nonpharmacologic approaches can improve fibromyalgia symptoms '
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Episode 636: Amitriptyline, duloxetine, and pregabalin each effective in decreasing pain from diabetic peripheral neuropathy; combinations even better
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Amitriptyline, duloxetine, and pregabalin each effective in decreasing pain from diabetic peripheral neuropathy; combinations even better '
Download Episode 636 (mp3, 5.1MB)
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Episode 635: Liraglutide probably the best second drug to prevent cardiovascular events in patients with T2DM who take metformin
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Liraglutide probably the best second drug to prevent cardiovascular events in patients with T2DM who take metformin '
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Episode 634: Polypill better for secondary cardiovascular prevention than physician-directed care
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Polypill better for secondary cardiovascular prevention than physician-directed care '
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Episode 633: Nirmatrelvir/ritonavir (Paxlovid) reduces hospitalization, mortality in patients 65+ with COVID-19; effect on younger patients unclear
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Nirmatrelvir/ritonavir (Paxlovid) reduces hospitalization, mortality in patients 65+ with COVID-19; effect on younger patients unclear '
Download Episode 633 (mp3, 5.7MB)
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Episode 632: Likelihood of long COVID varies by variant, sex, and vaccination status
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Likelihood of long COVID varies by variant, sex, and vaccination status '
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Episode 631: Pharmacogenomic testing for selection of antidepressant provides minimal, if any, benefit (PRIME)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Overuse alert: Pharmacogenomic testing for selection of antidepressant provides minimal, if any, benefit (PRIME) '
Download Episode 631 (mp3, 7.9MB)
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Episode 630: Greater social determinants of health burden associated with an increased risk of hospitalization
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Greater social determinants of health burden associated with an increased risk of hospitalization '
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Episode 629: Tirzepatide helps obese adults without diabetes lose 15% to 21% of their body weight over 72 weeks
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Tirzepatide helps obese adults without diabetes lose 15% to 21% of their body weight over 72 weeks '
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Episode 628: Supplemental vitamin D does not reduce the risk of fracture in older adults (VITAL)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Supplemental vitamin D does not reduce the risk of fracture in older adults (VITAL) '
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Episode 627: Screening for atrial fibrillation in primary care is not effective (VITAL-AF)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Screening for atrial fibrillation in primary care is not effective (VITAL-AF) '
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Episode 626: Fewer than 4% of children with newly diagnosed hypertension in primary care or school settings have secondary causes
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Fewer than 4% of children with newly diagnosed hypertension in primary care or school settings have secondary causes '
Download Episode 626 (mp3, 4.6MB)
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Episode 625: Minimal difference, if any, in the efficacy of intramuscular vs intra-articular steroid injection for knee osteoarthritis
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Minimal difference, if any, in the efficacy of intramuscular vs intra-articular steroid injection for knee osteoarthritis '
Download Episode 625 (mp3, 5.4MB)
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Episode 624: Long-term risks are similar for CT and invasive coronary angiography as initial diagnostic strategy for stable chest pain
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Long-term risks are similar for CT and invasive coronary angiography as initial diagnostic strategy for stable chest pain '
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Episode 623: Medication abortion for pregnancy of unknown location a reasonable option
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Medication abortion for pregnancy of unknown location a reasonable option '
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Episode 623: Medication abortion for pregnancy of unknown location a reasonable option
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Medication abortion for pregnancy of unknown location a reasonable option '
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Episode 622: USPSTF 2022 recommends against initiating aspirin for primary prevention of cardiovascular disease in adults 60+ years (D recommendation)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' USPSTF 2022 recommends against initiating aspirin for primary prevention of cardiovascular disease in adults 60+ years (D recommendation) '
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Episode 621: Aducanumab is not effective for mild cognitive impairment or mild Alzheimer's dementia and has major safety issues
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Aducanumab is not effective for mild cognitive impairment or mild Alzheimer's dementia and has major safety issues '
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Episode 620: Surgery is no better than nonoperative treatment for Achilles tendon rupture in adults
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Surgery is no better than nonoperative treatment for Achilles tendon rupture in adults '
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Episode 619: Ketamine reduces suicidal ideation quickly, but may not reduce the short-term likelihood of suicide attempts
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Ketamine reduces suicidal ideation quickly, but may not reduce the short-term likelihood of suicide attempts '
Download Episode 619 (mp3, 5.4MB)
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Episode 618: Combination antidepressant therapy is more effective than monotherapy for acute severe depression and nonresponding depression
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Combination antidepressant therapy is more effective than monotherapy for acute severe depression and nonresponding depression '
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Episode 617: Closed-loop system improves glycemic control but not hypoglycemia for young children with type 1 diabetes mellitus
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Closed-loop system improves glycemic control but not hypoglycemia for young children with type 1 diabetes mellitus '
Download Episode 617 (mp3, 4.5MB)
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Episode 616: Selective serotonin reuptake inhibitors are probably the best first option for patients with panic disorder
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Selective serotonin reuptake inhibitors are probably the best first option for patients with panic disorder '
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Episode 615: All-cause mortality is comparable in patients with left main coronary artery disease treated with PCI or CABG
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' All-cause mortality is comparable in patients with left main coronary artery disease treated with PCI or CABG '
Download Episode 615 (mp3, 4.6MB)
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Episode 614: MA: Several drugs are effective for weight loss in obese or overweight adults; it's unclear whether they improve health outcomes
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' MA: Several drugs are effective for weight loss in obese or overweight adults; it's unclear whether they improve health outcomes '
Download Episode 614 (mp3, 6.4MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 613: Large increases in the risk of cardiovascular events following COVID-19 infection that required hospitalization
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Large increases in the risk of cardiovascular events following COVID-19 infection that required hospitalization '
Download Episode 613 (mp3, 6.7MB)
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Episode 612: Thromboprophylaxis after discharge improves clinical outcomes for certain high-risk patients hospitalized with COVID-19 (MICHELLE)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Thromboprophylaxis after discharge improves clinical outcomes for certain high-risk patients hospitalized with COVID-19 (MICHELLE) '
Download Episode 612 (mp3, 5.7MB)
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Episode 611: Ibuprofen, ketorolac, and diclofenac are equivalent for the treatment of acute nonradicular low back pain
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Ibuprofen, ketorolac, and diclofenac are equivalent for the treatment of acute nonradicular low back pain '
Download Episode 611 (mp3, 4.9MB)
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Episode 611: Ibuprofen, ketorolac, and diclofenac are equivalent for the treatment of acute nonradicular low back pain
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Ibuprofen, ketorolac, and diclofenac are equivalent for the treatment of acute nonradicular low back pain '
Download Episode 611 (mp3, 4.9MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 610: Proton pump inhibitor use associated with an increased risk of gastric cancer
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Proton pump inhibitor use associated with an increased risk of gastric cancer '
Download Episode 610 (mp3, 6.4MB)
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Episode 609: British Society of Gastroenterology guidelines for the management of irritable bowel syndrome
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' British Society of Gastroenterology guidelines for the management of irritable bowel syndrome '
Download Episode 609 (mp3, 6.1MB)
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Episode 608: Nirmatrelvir/ritonavir (Paxlovid) reduces risk of hospitalization in at-risk outpatients (EPIC-HR)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Nirmatrelvir/ritonavir (Paxlovid) reduces risk of hospitalization in at-risk outpatients (EPIC-HR) '
Download Episode 608 (mp3, 6.3MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 607: No improved patient-oriented outcomes with sacubitril/valsartan in adults with heart failure and preserved EF (PARALLAX)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' No improved patient-oriented outcomes with sacubitril/valsartan in adults with heart failure and preserved EF (PARALLAX) '
Download Episode 607 (mp3, 6.1MB)
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Episode 606: Amoxicillin for children with CAP: low-dose for 3 days is noninferior to high-dose for 7 days (CAP-IT)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Amoxicillin for children with CAP: low-dose for 3 days is noninferior to high-dose for 7 days (CAP-IT) '
Download Episode 606 (mp3, 5.3MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 605: Lowering blood pressure does not decrease the risk of T2DM in persons with hypertension; ACEIs/ARBs do
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Lowering blood pressure does not decrease the risk of T2DM in persons with hypertension; ACEIs/ARBs do '
Download Episode 605 (mp3, 6MB)
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Episode 604: DAPT with aspirin plus clopidogrel for 30 days is the best option after minor stroke or TIA
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' DAPT with aspirin plus clopidogrel for 30 days is the best option after minor stroke or TIA '
Download Episode 604 (mp3, 5.9MB)
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Episode 603: For mild/moderate acne, adapalene + BPO, clindamycin + BPO, and adapalene alone are most effective, in that order
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' For mild/moderate acne, adapalene + BPO, clindamycin + BPO, and adapalene alone are most effective, in that order '
Download Episode 603 (mp3, 6.6MB)
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Episode 602: Platelet-rich plasma injections are not superior to placebo injections for ankle osteoarthritis
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Platelet-rich plasma injections are not superior to placebo injections for ankle osteoarthritis '
Download Episode 602 (mp3, 3.9MB)
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Episode 601: Midodrine is worth a trial in people with frequent episodes of vasovagal syncope
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Midodrine is worth a trial in people with frequent episodes of vasovagal syncope '
Download Episode 601 (mp3, 5.4MB)
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Episode 600: In-office procalcitonin testing can lead to less antibiotic prescribing
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' In-office procalcitonin testing can lead to less antibiotic prescribing '
Download Episode 600 (mp3, 6.1MB)
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Episode 599: Empagliflozin reduces hospitalization for heart failure with preserved ejection fraction (NNT = 59 per year), but not mortality outcomes (EMPEROR-Preserved)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Empagliflozin reduces hospitalization for heart failure with preserved ejection fraction (NNT = 59 per year), but not mortality outcomes (EMPEROR-Preserved) '
Download Episode 599 (mp3, 6.2MB)
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Episode 598: Relapse of depression more likely after discontinuation of medication (number needed to treat to harm = 6).
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Relapse of depression more likely after discontinuation of medication (number needed to treat to harm = 6). '
Download Episode 598 (mp3, 7.1MB)
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Episode 597: Amoxicillin does not improve outcomes for nonpneumonia lower respiratory tract infection in children (ARTIC PC)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Amoxicillin does not improve outcomes for nonpneumonia lower respiratory tract infection in children (ARTIC PC) '
Download Episode 597 (mp3, 6MB)
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Episode 596: Predictive values for 6 common abdominal symptoms
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Predictive values for 6 common abdominal symptoms '
Download Episode 596 (mp3, 5.8MB)
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Episode 596: Predictive values for 6 common abdominal symptoms
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Predictive values for 6 common abdominal symptoms '
Download Episode 596 (mp3, 5.8MB)
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- Predictive values for 6 common abdominal symptoms
- Ibuprofen, ketorolac, and diclofenac are equivalent for the treatment of acute nonradicular low back pain
- Low FODMAPS diet is better than an oral spasmolytic for irritable bowel syndrome (NNT = 7 – 9)
- Medication abortion for pregnancy of unknown location a reasonable option
Episode 595: Some patients are willing to consider delayed antibiotic treatment of respiratory tract infection
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Some patients are willing to consider delayed antibiotic treatment of respiratory tract infection '
Download Episode 595 (mp3, 7.7MB)
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Episode 594: Only one cerumenolytic assists with in-office manual disimpaction of ear wax
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Only one cerumenolytic assists with in-office manual disimpaction of ear wax '
Download Episode 594 (mp3, 6MB)
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Episode 593: Salt substitute reduces mortality and stroke in elderly patients who have a history of, or are at risk of, stroke
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Salt substitute reduces mortality and stroke in elderly patients who have a history of, or are at risk of, stroke '
Download Episode 593 (mp3, 6.8MB)
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Episode 592: Universal depression screening in primary care: 77% false positives
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Universal depression screening in primary care: 77% false positives '
Download Episode 592 (mp3, 6MB)
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Episode 591: Iron supplementation in infants living in countries with a high prevalence of anemia does not improve cognition or development
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Iron supplementation in infants living in countries with a high prevalence of anemia does not improve cognition or development '
Download Episode 591 (mp3, 6.3MB)
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Episode 590: Evidence of benefit is lacking for low back pain relief with muscle relaxants
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Evidence of benefit is lacking for low back pain relief with muscle relaxants '
Download Episode 590 (mp3, 7.5MB)
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Episode 589: Every-other-year FIT is at least as effective as a single sigmoidoscopy to detect colorectal cancer
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Every-other-year FIT is at least as effective as a single sigmoidoscopy to detect colorectal cancer '
Download Episode 589 (mp3, 6.6MB)
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Episode 588: Third Pfizer vaccine dose significantly increases protection against both mild and severe COVID-19 in patients 60 years+
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Third Pfizer vaccine dose significantly increases protection against both mild and severe COVID-19 in patients 60 years+ '
Download Episode 588 (mp3, 7.3MB)
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Episode 587: Guidelines for when to consider mortality-reducing treatments for patients with type 2 diabetes
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Guidelines for when to consider mortality-reducing treatments for patients with type 2 diabetes '
Download Episode 587 (mp3, 5.3MB)
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Episode 586: Telephone-based cognitive behavioral therapy for insomnia is effective
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Telephone-based cognitive behavioral therapy for insomnia is effective '
Download Episode 586 (mp3, 6.2MB)
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Episode 585: High-frequency spinal cord stimulation improves pain in patients with refractory painful diabetic neuropathy
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' High-frequency spinal cord stimulation improves pain in patients with refractory painful diabetic neuropathy '
Download Episode 585 (mp3, 7.4MB)
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Episode 584: AHA guideline for secondary stroke prevention
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' AHA guideline for secondary stroke prevention '
Download Episode 584 (mp3, 5.4MB)
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Episode 583: Left atrial appendage occlusion during cardiac surgery for another reason reduces the risk of stroke (NNT = 43 over 4 years)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Left atrial appendage occlusion during cardiac surgery for another reason reduces the risk of stroke (NNT = 43 over 4 years) '
Download Episode 583 (mp3, 5.4MB)
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Episode 582: Some nonpharmacological treatments may decrease migraine frequency in children and adolescents
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Some nonpharmacological treatments may decrease migraine frequency in children and adolescents '
Download Episode 582 (mp3, 5.5MB)
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Episode 581: Ultrasound is accurate for diagnosing upper extremity fractures in children
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Ultrasound is accurate for diagnosing upper extremity fractures in children '
Download Episode 581 (mp3, 5.2MB)
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Episode 580: Routine MRI reports for low back pain may decrease function and worsen pain because of Catastrophizing language
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Routine MRI reports for low back pain may decrease function and worsen pain because of Catastrophizing language '
Download Episode 580 (mp3, 5.5MB)
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Episode 579: Dual antiplatelet therapy is superior to aspirin in preventing short-term recurrent stroke at the cost of more major bleeding
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Dual antiplatelet therapy is superior to aspirin in preventing short-term recurrent stroke at the cost of more major bleeding '
Download Episode 579 (mp3, 4.8MB)
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Episode 578: Screening for ovarian cancer with CA-125/ultrasound algorithm does not reduce mortality (UKCTOCS)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Screening for ovarian cancer with CA-125/ultrasound algorithm does not reduce mortality (UKCTOCS) '
Download Episode 578 (mp3, 8.4MB)
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Episode 577: Anticonvulsants, SNRIs, and rubefacients are best initial choices for chronic pain caused by diabetic neuropathy or postherpetic neuralgia
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Anticonvulsants, SNRIs, and rubefacients are best initial choices for chronic pain caused by diabetic neuropathy or postherpetic neuralgia '
Download Episode 577 (mp3, 6.5MB)
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Episode 576: Five days of antibiotic therapy is comparable with 10 days in children with community-acquired pneumonia (SAFER)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Five days of antibiotic therapy is comparable with 10 days in children with community-acquired pneumonia (SAFER) '
Download Episode 576 (mp3, 6.6MB)
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Episode 575: USPSTF 2021 now recommends colorectal screening beginning at age 45 years (B recommendation)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' USPSTF 2021 now recommends colorectal screening beginning at age 45 years (B recommendation) '
Download Episode 575 (mp3, 6.4MB)
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Episode 574: Antibiotic therapy does not prevent death or acute exacerbations in adults with idiopathic pulmonary fibrosis
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Antibiotic therapy does not prevent death or acute exacerbations in adults with idiopathic pulmonary fibrosis '
Download Episode 574 (mp3, 4.3MB)
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Episode 573: No difference in cognitive decline in elderly patients with coronary artery disease undergoing CABG vs PCI
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' No difference in cognitive decline in elderly patients with coronary artery disease undergoing CABG vs PCI '
Download Episode 573 (mp3, 4.5MB)
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Episode 572: For patients with type 2 diabetes mellitus who are taking a GLP-1, SGLT2 may be preferred to a sulfonylurea as add-on therapy
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' For patients with type 2 diabetes mellitus who are taking a GLP-1, SGLT2 may be preferred to a sulfonylurea as add-on therapy '
Download Episode 572 (mp3, 5.7MB)
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Episode 571: Inhaled budesonide reduces the risk of emergency department evaluation or hospitalization in early COVID-19
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Inhaled budesonide reduces the risk of emergency department evaluation or hospitalization in early COVID-19 '
Download Episode 571 (mp3, 4.7MB)
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Episode 570: The risk of progression from prediabetes to diabetes in older adults is low
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' The risk of progression from prediabetes to diabetes in older adults is low '
Download Episode 570 (mp3, 4.5MB)
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Episode 569: The probability of disease is frequently overestimated by primary care clinicians
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' The probability of disease is frequently overestimated by primary care clinicians '
Download Episode 569 (mp3, 8.2MB)
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Episode 568: Epidural steroid injections provide minimal, if any, benefit in low back pain with sciatica
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Epidural steroid injections provide minimal, if any, benefit in low back pain with sciatica '
Download Episode 568 (mp3, 6.9MB)
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Episode 567: Once-weekly semaglutide is an effective adjunct for weight loss in nondiabetic overweight/obese adults (STEP 3)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Once-weekly semaglutide is an effective adjunct for weight loss in nondiabetic overweight/obese adults (STEP 3) '
Download Episode 567 (mp3, 7MB)
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Episode 566: Rapid antigen tests for COVID-19 are much less sensitive in asymptomatic persons (40% vs 80% in symptomatic persons)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Rapid antigen tests for COVID-19 are much less sensitive in asymptomatic persons (40% vs 80% in symptomatic persons) '
Download Episode 566 (mp3, 5.4MB)
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Episode 565: Single-dose opioid analgesics offer no benefit over non-narcotic analgesia for musculoskeletal pain
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Single-dose opioid analgesics offer no benefit over non-narcotic analgesia for musculoskeletal pain '
Download Episode 565 (mp3, 4.5MB)
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Episode 564: Cryoablation preferred as initial therapy for paroxysmal atrial fibrillation (EARLY-AF)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Cryoablation preferred as initial therapy for paroxysmal atrial fibrillation (EARLY-AF) '
Download Episode 564 (mp3, 4.8MB)
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Episode 563: Ticagrelor plus aspirin is superior to aspirin alone in preventing stroke after TIA or minor stroke (THALES)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Ticagrelor plus aspirin is superior to aspirin alone in preventing stroke after TIA or minor stroke (THALES) '
Download Episode 563 (mp3, 4.8MB)
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Episode 562: Tighter blood pressure control does not increase the likelihood of orthostatic hypotension
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Tighter blood pressure control does not increase the likelihood of orthostatic hypotension '
Download Episode 562 (mp3, 4.4MB)
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Episode 561: SR: Exercise is the only intervention to provide long-term improvement in patients with chronic low back pain
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' SR: Exercise is the only intervention to provide long-term improvement in patients with chronic low back pain '
Download Episode 561 (mp3, 6.4MB)
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Episode 560: Limited role for antidepressants in back pain and osteoarthritis pain
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Limited role for antidepressants in back pain and osteoarthritis pain '
Download Episode 560 (mp3, 5.6MB)
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Episode 559: SGLT-2 inhibitors or GLP-1 receptor agonists reduce cardiovascular outcomes in patients with type 2 diabetes
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' SGLT-2 inhibitors or GLP-1 receptor agonists reduce cardiovascular outcomes in patients with type 2 diabetes '
Download Episode 559 (mp3, 7.2MB)
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Episode 558: Low-carb diets may produce short-term diabetes remission
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Low-carb diets may produce short-term diabetes remission '
Download Episode 558 (mp3, 6.1MB)
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Episode 557: Positive CA125 test results for "symptomatic" women are wrong most of the time
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Positive CA125 test results for "symptomatic" women are wrong most of the time '
Download Episode 557 (mp3, 6.9MB)
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Episode 556: Approximately 1 in 6 household and family contacts become infected with SARS-CoV-2
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Approximately 1 in 6 household and family contacts become infected with SARS-CoV-2 '
Download Episode 556 (mp3, 7.2MB)
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Episode 555: Lipid lowering is beneficial for secondary prevention but not primary prevention in patients 75 years and older
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Lipid lowering is beneficial for secondary prevention but not primary prevention in patients 75 years and older '
Download Episode 555 (mp3, 6.9MB)
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Episode 554: Eating eggs is not associated with cardiovascular disease
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Eating eggs is not associated with cardiovascular disease '
Download Episode 554 (mp3, 5.8MB)
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Episode 553: Continuous glucose monitoring adds little benefit, especially in adults
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Continuous glucose monitoring adds little benefit, especially in adults '
Download Episode 553 (mp3, 4.7MB)
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Episode 552: Colchicine reduces myocardial infarction and revascularization in patients with established coronary disease (LoDoCo2)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Colchicine reduces myocardial infarction and revascularization in patients with established coronary disease (LoDoCo2) '
Download Episode 552 (mp3, 5.8MB)
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Episode 551: Early introduction of dietary gluten delays the diagnosis of celiac disease in breastfed infants (EAT)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Early introduction of dietary gluten delays the diagnosis of celiac disease in breastfed infants (EAT) '
Download Episode 551 (mp3, 4.5MB)
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Episode 550: SGLT2 inhibitors ("-flozin" meds) improve all-cause and CV mortality in patients regardless of diabetes or HF status
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' SGLT2 inhibitors ("-flozin" meds) improve all-cause and CV mortality in patients regardless of diabetes or HF status '
Download Episode 550 (mp3, 5.8MB)
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Episode 549: Screening smokers for lung cancer with low-dose CT decreases lung cancer mortality
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Screening smokers for lung cancer with low-dose CT decreases lung cancer mortality '
Download Episode 549 (mp3, 8.7MB)
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Episode 548: iCanQuit smartphone app is effective in helping with smoking cessation
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' iCanQuit smartphone app is effective in helping with smoking cessation '
Download Episode 548 (mp3, 4.8MB)
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Episode 547: Gabapentin is equal to placebo for pain relief in women with chronic pelvic pain (GaPP2), but with more side effects
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Gabapentin is equal to placebo for pain relief in women with chronic pelvic pain (GaPP2), but with more side effects '
Download Episode 547 (mp3, 5.3MB)
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Episode 546: Musculoskeletal surgery for nontraumatic pain: not a great analgesic
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Musculoskeletal surgery for nontraumatic pain: not a great analgesic '
Download Episode 546 (mp3, 5.4MB)
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Episode 545: In high-risk older patients with atrial fibrillation, rhythm control reduces cardiovascular death and stroke, but at a price
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' In high-risk older patients with atrial fibrillation, rhythm control reduces cardiovascular death and stroke, but at a price '
Download Episode 545 (mp3, 6.9MB)
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Episode 544: Human papillomavirus vaccine, especially before age 17, is associated with a large reduction in invasive cervical cancer
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Human papillomavirus vaccine, especially before age 17, is associated with a large reduction in invasive cervical cancer '
Download Episode 544 (mp3, 6.5MB)
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Episode 543: Low-dose edoxaban effective for stroke prevention for elderly patients with atrial fibrillation
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Low-dose edoxaban effective for stroke prevention for elderly patients with atrial fibrillation '
Download Episode 543 (mp3, 4.4MB)
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Episode 542: Three strategies are effective in managing patients with medication overuse headaches
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Three strategies are effective in managing patients with medication overuse headaches '
Download Episode 542 (mp3, 5.2MB)
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Episode 541: Better primary care continuity is associated with lower mortality risk
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Better primary care continuity is associated with lower mortality risk '
Download Episode 541 (mp3, 6.5MB)
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Episode 540: The balance of benefits and harms no longer favors aspirin for primary prevention
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' The balance of benefits and harms no longer favors aspirin for primary prevention '
Download Episode 540 (mp3, 6.2MB)
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Episode 539: Pay attention to gut feelings about cancer in patients
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Pay attention to gut feelings about cancer in patients '
Download Episode 539 (mp3, 6MB)
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Episode 538: BMD testing: one and done
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' BMD testing: one and done '
Download Episode 538 (mp3, 6.2MB)
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Episode 537: Progression of papillary thyroid cancer is lower in older adults
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Progression of papillary thyroid cancer is lower in older adults '
Download Episode 537 (mp3, 5.2MB)
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Episode 536: Negative colonoscopy result predicts no colon cancer for more than 10 years
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Negative colonoscopy result predicts no colon cancer for more than 10 years '
Download Episode 536 (mp3, 6.6MB)
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Episode 535: Vibegron effective versus placebo but not tolterodine for adults with overactive bladder symptoms (EMPOWUR)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Vibegron effective versus placebo but not tolterodine for adults with overactive bladder symptoms (EMPOWUR) '
Download Episode 535 (mp3, 4.8MB)
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Episode 534: Fewer subsequent strokes with ticagrelor plus aspirin than with aspirin alone
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Fewer subsequent strokes with ticagrelor plus aspirin than with aspirin alone '
Download Episode 534 (mp3, 5.1MB)
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Episode 533: 20-year follow-up of WHI trials: lower breast cancer mortality with CEE alone, no difference with CEE plus progesterone
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' 20-year follow-up of WHI trials: lower breast cancer mortality with CEE alone, no difference with CEE plus progesterone '
Download Episode 533 (mp3, 5.5MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 532: American College of Rheumatology guideline for managing patients with gout
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' American College of Rheumatology guideline for managing patients with gout '
Download Episode 532 (mp3, 5.7MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 531: Listen for clues that indicate which patients who are taking opioids may be open to other options
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Listen for clues that indicate which patients who are taking opioids may be open to other options '
Download Episode 531 (mp3, 6.3MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 530: Short-term low back pain relief with placebo
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Short-term low back pain relief with placebo '
Download Episode 530 (mp3, 6.6MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 529: Triple inhaled therapy provides a small reduction in moderate exacerbations, no effect on severe exacerbations (ETHOS)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Triple inhaled therapy provides a small reduction in moderate exacerbations, no effect on severe exacerbations (ETHOS) '
Download Episode 529 (mp3, 7.6MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 528: Buffering lidocaine 1%/epinephrine with sodium bicarbonate in a 3:1 ratio is as effective and less painful than a 9:1 ratio
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Buffering lidocaine 1%/epinephrine with sodium bicarbonate in a 3:1 ratio is as effective and less painful than a 9:1 ratio '
Download Episode 528 (mp3, 4.5MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 527: Self-diagnosis of uncomplicated urinary tract infections usually confirmed and treated via telemedicine visits
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Self-diagnosis of uncomplicated urinary tract infections usually confirmed and treated via telemedicine visits '
Download Episode 527 (mp3, 5.8MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 526: A specific probiotic decreases crying in colicky infants younger than 2 months
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' A specific probiotic decreases crying in colicky infants younger than 2 months '
Download Episode 526 (mp3, 3.9MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 525: Terbinafine and itraconazole are most effective for toenail onychomycosis
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Terbinafine and itraconazole are most effective for toenail onychomycosis '
Download Episode 525 (mp3, 4.6MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 524: Low-dose aspirin beneficial for the prevention of preterm birth in nulliparas with singleton pregnancy
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Low-dose aspirin beneficial for the prevention of preterm birth in nulliparas with singleton pregnancy '
Download Episode 524 (mp3, 5.2MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 523: Cycled hyperbaric oxygen improves the healing of diabetic foot ulcers
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Cycled hyperbaric oxygen improves the healing of diabetic foot ulcers '
Download Episode 523 (mp3, 5.2MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 522: Antibiotic and corticosteroid treatment effective for acute exacerbations of COPD
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Antibiotic and corticosteroid treatment effective for acute exacerbations of COPD '
Download Episode 522 (mp3, 4MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 521: Increased daily steps associated with reduced all-cause mortality
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Increased daily steps associated with reduced all-cause mortality '
Download Episode 521 (mp3, 5.9MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 520: Watch-and-wait strategy is an option for primary spontaneous pneumothorax
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Watch-and-wait strategy is an option for primary spontaneous pneumothorax '
Download Episode 520 (mp3, 4.6MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 519: C-reactive protein is the most useful biomarker for diagnosis of outpatient community-acquired pneumonia
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' C-reactive protein is the most useful biomarker for diagnosis of outpatient community-acquired pneumonia '
Download Episode 519 (mp3, 5.7MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 518: COVID-19 research briefs: 44% of secondary infections of SARS-CoV2 occur when the index case is presymptomatic
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' COVID-19 research briefs: 44% of secondary infections of SARS-CoV2 occur when the index case is presymptomatic '
Download Episode 518 (mp3, 3.9MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 517: Similar long-term morbidity and mortality with human insulin and analogue insulins
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Similar long-term morbidity and mortality with human insulin and analogue insulins '
Download Episode 517 (mp3, 4.1MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 516: American College of Rheumatology guideline for managing patients with degenerative joint disease of the hand, knee, and hip
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' American College of Rheumatology guideline for managing patients with degenerative joint disease of the hand, knee, and hip '
Download Episode 516 (mp3, 4.1MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 515: Fecal microbiota transplant effective for irritable bowel syndrome
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Fecal microbiota transplant effective for irritable bowel syndrome '
Download Episode 515 (mp3, 7MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 514: Daily colchicine post-MI reduces strokes and recurrent hospitalizations for angina (COLCOT)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Daily colchicine post-MI reduces strokes and recurrent hospitalizations for angina (COLCOT) '
Download Episode 514 (mp3, 5.8MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 513: Denosumab no better than bisphosphonates at preventing fracture, and the cost is much higher
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Denosumab no better than bisphosphonates at preventing fracture, and the cost is much higher '
Download Episode 513 (mp3, 5.6MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 512: COVID-19 research briefs: SARS-CoV-2 may increase stroke rate in patients younger than 50, and remdesivir shortens recovery
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' COVID-19 research briefs: SARS-CoV-2 may increase stroke rate in patients younger than 50, and remdesivir shortens recovery '
Download Episode 512 (mp3, 6.1MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 511: Prophylaxis with continuous IV haloperidol decreased post-op delirium in elderly
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Prophylaxis with continuous IV haloperidol decreased post-op delirium in elderly '
Download Episode 511 (mp3, 4.6MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 510: Pragmatic trial: Oseltamivir of uncertain benefit in patients with flu-like symptoms
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Pragmatic trial: Oseltamivir of uncertain benefit in patients with flu-like symptoms '
Download Episode 510 (mp3, 9.6MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 509: Small reduction in CV outcome after ischemic stroke with lower LDL target, but also harms; no change in all-cause mortality
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Small reduction in CV outcome after ischemic stroke with lower LDL target, but also harms; no change in all-cause mortality '
Download Episode 509 (mp3, 6.6MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 508: Mailing FIT or gFOBT directly to patients increases uptake of colorectal cancer screening
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Mailing FIT or gFOBT directly to patients increases uptake of colorectal cancer screening '
Download Episode 508 (mp3, 5.5MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 507: Increasing the D-dimer threshold for patients with low clinical pretest probability effectively rules out PE (PEGeD)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Increasing the D-dimer threshold for patients with low clinical pretest probability effectively rules out PE (PEGeD) '
Download Episode 507 (mp3, 6.5MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 506: No cow's milk formula for the first 3 days of life prevents food allergies
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' No cow's milk formula for the first 3 days of life prevents food allergies '
Download Episode 506 (mp3, 3.4MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 505: Rates of adverse effects of treatment for otitis media varies by antibiotic and dose
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Rates of adverse effects of treatment for otitis media varies by antibiotic and dose '
Download Episode 505 (mp3, 5.4MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 504: COVID-19 research briefs: (1) a case series of convalescent sera, and (2) a negative trial of hydroxychloroquine
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' COVID-19 research briefs: (1) a case series of convalescent sera, and (2) a negative trial of hydroxychloroquine'
Download Episode 504 (mp3, 3.8MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 503: Useful signs and symptoms for diagnosing hip osteoarthritis
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Useful signs and symptoms for diagnosing hip osteoarthritis '
Download Episode 503 (mp3, 4.9MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 502: Supplemental MRI screening in women with very dense breasts reduces interval cancer rate but may cause overdiagnosis (DENSE)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Supplemental MRI screening in women with very dense breasts reduces interval cancer rate but may cause overdiagnosis (DENSE) '
Download Episode 502 (mp3, 6.9MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 501: Being a former professional soccer player is associated with an increased risk of neurodegenerative disease
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Being a former professional soccer player is associated with an increased risk of neurodegenerative disease '
Download Episode 501 (mp3, 7.9MB)
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Episode 500: Mind-body treatments enhance opioid treatment of patients with acute or chronic pain
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Mind-body treatments enhance opioid treatment of patients with acute or chronic pain"
Download Episode 500 (mp3, 0.7MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 499: For 3-vessel disease (but not left main disease), CABG is preferred over PCI
Dr. Ebell and Dr. Wilkes discuss the POEM titled "For 3-vessel disease (but not left main disease), CABG is preferred over PCI"
Download Episode 499 (mp3, 0.5MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 498: No short-term extra benefit when muscle relaxants are added to ibuprofen for acute low back pain
Dr. Ebell and Dr. Wilkes discuss the POEM titled "No short-term extra benefit when muscle relaxants are added to ibuprofen for acute low back pain"
Download Episode 498 (mp3, 0.5MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 497: Nonpharmacologic approaches are better than medication to control aggression/agitation in dementia
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Nonpharmacologic approaches are better than medication to control aggression/agitation in dementia"
Download Episode 497 (mp3, 0.5MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 496: Autism Screening with Follow-up
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Autism Screening with Follow-up"
Download Episode 496 (mp3, 0.7MB)
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Episode 495: Five days of penicillin for strep throat is equal to 10 days
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Five days of penicillin for strep throat is equal to 10 days"
Download Episode 495 (mp3, 0.6MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 494: Adding ibuprofen and codeine to acetaminophen does not improve pain relief for acute musculoskeletal injury
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Adding ibuprofen and codeine to acetaminophen does not improve pain relief for acute musculoskeletal injury"
Download Episode 494 (mp3, 0.5MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 493: Results of fecal immunochemical tests for colorectal cancer screening not affected by NSAIDs, aspirin, or anticoagulants
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Results of fecal immunochemical tests for colorectal cancer screening not affected by NSAIDs, aspirin, or anticoagulants"
Download Episode 493 (mp3, 0.6MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 492: Equivalent pain relief with different doses of ibuprofen
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Equivalent pain relief with different doses of ibuprofen"
Download Episode 492 (mp3, 0.5MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 491: Bedtime instead of morning ingestion of hypertension meds = significantly more reduction in cardiovascular disease risk
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Bedtime instead of morning ingestion of hypertension meds = significantly more reduction in cardiovascular disease risk"
Download Episode 491 (mp3, 0.6MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 490: no benefit to routine antipsychotic use for treatment of delirium in hospitalized patients
Dr. Ebell and Dr. Wilkes discuss the POEM titled "no benefit to routine antipsychotic use for treatment of delirium in hospitalized patients"
Download Episode 490 (mp3, 0.5MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 489: Fewer severe exacerbations in pts with mild-moderate asthma treated with budesonide and formoterol
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Fewer severe exacerbations in pts with mild-moderate asthma treated with budesonide and formoterol"
Download Episode 489 (mp3, 0.4MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 488: Linagliptin and glimepiride equally effective for adults with DM2
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Linagliptin and glimepiride equally effective for adults with DM2"
Download Episode 488 (mp3, 0.6MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 487: Guidelines on medications for acute treatment and prevention of migraines in children and adolescents
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Guidelines on medications for acute treatment and prevention of migraines in children and adolescents"
Download Episode 487 (mp3, 0.6MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 486: Surgery or lasers preferred to foam sclerotherapy for varicose veins
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Surgery or lasers preferred to foam sclerotherapy for varicose veins"
Download Episode 486 (mp3, 0.5MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 485: C-reactive protein guidance safely reduces antibiotic use in patients with acute exacerbation of COPD (NNT = 5)
Dr. Ebell and Dr. Wilkes discuss the POEM titled "C-reactive protein guidance safely reduces antibiotic use in patients with acute exacerbation of COPD (NNT = 5)"
Download Episode 485 (mp3, 0.7MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 484: Adding dulaglutide only slightly decreases major adverse CV events in patients with T2DM and CVD risk factors (REWIND)
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Adding dulaglutide only slightly decreases major adverse CV events in patients with T2DM and CVD risk factors (REWIND)"
Download Episode 484 (mp3, 0.6MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 483: Fasting and nonfasting lipid levels similarly predict CVD risk
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Fasting and nonfasting lipid levels similarly predict CVD risk"
Download Episode 483 (mp3, 0.5MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 482: Topical interventions (eg, 5-FU, ingenol mebutate, and diclofenac) improve outcomes after cryosurgery for actinic keratosis
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Topical interventions (eg, 5-FU, ingenol mebutate, and diclofenac) improve outcomes after cryosurgery for actinic keratosis"
Download Episode 482 (mp3, 0.5MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 481: Baloxavir reduces symptom duration similarly to oseltamivir, primarily within 24 hours of symptom onset
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Baloxavir reduces symptom duration similarly to oseltamivir, primarily within 24 hours of symptom onset"
Download Episode 481 (mp3, 0.8MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 480: Platelet-rich plasma = saline for patients with patellar tendinopathy
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Platelet-rich plasma = saline for patients with patellar tendinopathy"
Download Episode 480 (mp3, 0.5MB)
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Episode 479: As-needed budesonide/formoterol similar to maintenance budesonide plus SABA in patients with mild asthma
Dr. Ebell and Dr. Wilkes discuss the POEM titled ""As-needed budesonide/formoterol similar to maintenance budesonide plus SABA in patients with mild asthma
Download Episode 479 (mp3, 0.5MB)
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Episode 478: One month of DAPT followed by clopidogrel alone is superior to 12 months of DAPT after PCI (STOPDAPT-2)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ""One month of DAPT followed by clopidogrel alone is superior to 12 months of DAPT after PCI (STOPDAPT-2)
Download Episode 478 (mp3, 0.5MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 477: Dabigatran reduces risk of stroke and embolism in patients with AF
Dr. Ebell and Dr. Wilkes discuss the POEM titled ""Dabigatran reduces risk of stroke and embolism in patients with AF
Download Episode 477 (mp3, 0.5MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 476: Steroids beneficial as adjunctive treatment for community-acquired pneumonia
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Steroids beneficial as adjunctive treatment for community-acquired pneumonia'
Download Episode 476 (mp3, 0.5MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 475: Treating opioid use disorder in primary care—limited data, but looks feasible
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Treating opioid use disorder in primary care—limited data, but looks feasible"
Download Episode 475 (mp3, 0.4MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 474: Do not change antidepressant treatment early based on a lack of response
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Do not change antidepressant treatment early based on a lack of response"
Download Episode 474 (mp3, 4.3MB)
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Episode 473: Adding ultrasound to mammography increases false-positive findings without an increase in cancer detection
Dr. Ebell and Dr. Wilkes discuss the POEM titled ""Adding ultrasound to mammography increases false-positive findings without an increase in cancer detection
Download Episode 473 (mp3, 0.5MB)
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Episode 472: "Augmentation" of antidepressant treatment offers little benefit
Dr. Ebell and Dr. Wilkes discuss the POEM titled ""Augmentation" of antidepressant treatment offers little benefit"
Download Episode 472 (mp3, 0.5MB)
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Episode 471: Platelet-rich plasma injection not beneficial for nonoperative treatment
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Platelet-rich plasma injection not beneficial for nonoperative treatment"
Download Episode 471 (mp3, 0.5MB)
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Episode 470: 5% fluorouracil is the preferred treatment for actinic keratoses
Dr. Ebell and Dr. Wilkes discuss the POEM titled "5% fluorouracil is the preferred treatment for actinic keratoses"
Download Episode 470 (mp3, 0.4MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 469: Normal vital signs and pulmonary exam results rule out CAP in adults with acute respiratory infection
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Normal vital signs and pulmonary exam results rule out CAP in adults with acute respiratory infection"
Download Episode 469 (mp3, 0.4MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 468: Oral = IV antibiotics for serious bone and joint infections
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Oral = IV antibiotics for serious bone and joint infections"
Download Episode 468 (mp3, 0.5MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 467: More expensive omadacycline no worse than moxifloxacin for community-acquired pneumonia
Dr. Ebell and Dr. Wilkes discuss the POEM titled "More expensive omadacycline no worse than moxifloxacin for community-acquired pneumonia"
Download Episode 467 (mp3, 0.6MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 466: E-cigarettes more effective than nicotine replacement for cessation of tobacco use in adults
Dr. Ebell and Dr. Wilkes discuss the POEM titled "E-cigarettes more effective than nicotine replacement for cessation of tobacco use in adults"
Download Episode 466 (mp3, 0.7MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 465: Monthly buprenorphine depot injections maintain abstinence in patients with opioid use disorders
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Monthly buprenorphine depot injections maintain abstinence in patients with opioid use disorders"
Download Episode 465 (mp3, 0.7MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 464: More evidence against antibiotics for acute asthma exacerbations
Dr. Ebell and Dr. Wilkes discuss the POEM titled "More evidence against antibiotics for acute asthma exacerbations"
Download Episode 464 (mp3, 0.6MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 463: Short-term clopidogrel + aspirin prevents second ischemic stroke better than aspirin alone
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Short-term clopidogrel + aspirin prevents second ischemic stroke better than aspirin alone"
Download Episode 463 (mp3, 0.5MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 462: Misoprostol alone is associated with high rate of successful first-trimester abortion
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Misoprostol alone is associated with high rate of successful first-trimester abortion"
Download Episode 462 (mp3, 0.6MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 461: Overview of new ACC/AHA lipid guidelines: here we go again
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Overview of new ACC/AHA lipid guidelines: here we go again"
Download Episode 461 (mp3, 0.3MB)
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Episode 460: Risk of GI bleeding highest with rivaroxaban, lower with apixaban… and lowest with PPI cotherapy
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Risk of GI bleeding highest with rivaroxaban, lower with apixaban… and lowest with PPI cotherapy"
Download Episode 460 (mp3, 0.6MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 459: Aspirin, eicosapentaenoic acid, and placebo equally effective in preventing colorectal adenomas in high-risk patients
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Aspirin, eicosapentaenoic acid, and placebo equally effective in preventing colorectal adenomas in high-risk patients"
Download Episode 459 (mp3, 0.6MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 458: Low-dose haloperidol does not prevent delirium after noncardiac thoracic surgery
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Low-dose haloperidol does not prevent delirium after noncardiac thoracic surgery"
Download Episode 458 (mp3, 0.5MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 457: Probiotic ineffective for treatment of acute gastroenteritis in young children
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Probiotic ineffective for treatment of acute gastroenteritis in young children"
Download Episode 457 (mp3, 0.5MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 456: In healthy elderly, low-dose aspirin increases all-cause and cancer-specific mortality (ASPREE)
Dr. Ebell and Dr. Wilkes discuss the POEM titled "In healthy elderly, low-dose aspirin increases all-cause and cancer-specific mortality (ASPREE)"
Download Episode 456 (mp3, 0.6MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 455: Omega-3 oil does not reduce serious cardiovascular events for patients with diabetes mellitus (ASCEND)
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Omega-3 oil does not reduce serious cardiovascular events for patients with diabetes mellitus (ASCEND)"
Download Episode 455 (mp3, 0.6MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 454: Both benefits and harms for low-dose aspirin in patients with diabetes mellitus (ASCEND)
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Both benefits and harms for low-dose aspirin in patients with diabetes mellitus (ASCEND)"
Download Episode 454 (mp3, 0.7MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 453: Simple clinical prediction rule determines risk of heart failure with preserved ejection fraction
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Simple clinical prediction rule determines risk of heart failure with preserved ejection fraction"
Download Episode 453 (mp3, 0.6MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 452: FIT has similar yield as colonoscopy for colorectal cancer and advanced adenoma over 10 years
Dr. Ebell and Dr. Wilkes discuss the POEM titled "FIT has similar yield as colonoscopy for colorectal cancer and advanced adenoma over 10 years"
Download Episode 452 (mp3, 0.8MB)
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Episode 451: Aspirin's benefits and harms are less clear for primary prevention in moderate-risk patients (ARRIVE)
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Aspirin's benefits and harms are less clear for primary prevention in moderate-risk patients (ARRIVE)"
Download Episode 451 (mp3, 0.6MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 450: No reduction in delirium with the use of haloperidol or ziprasidone in critically ill patients
Dr. Ebell and Dr. Wilkes discuss the POEM titled "No reduction in delirium with the use of haloperidol or ziprasidone in critically ill patients"
Download Episode 450 (mp3, 0.6MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 449: Failure to wear a helmet while motorcycling is bad for your head
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Failure to wear a helmet while motorcycling is bad for your head"
Download Episode 449 (mp3, 0.6MB)
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Episode 448: Limited data: deprescribing is safe, but at the risk of symptom recurrence
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Limited data: deprescribing is safe, but at the risk of symptom recurrence"
Download Episode 448 (mp3, 0.7MB)
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Episode 447: Aspirin alone may be sufficient protection from postop VTE after total knee arthroplasty
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Aspirin alone may be sufficient protection from postop VTE after total knee arthroplasty"
Download Episode 447 (mp3, 0.5MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 446: Sometimes our word choices turn good news into bad news
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Sometimes our word choices turn good news into bad news"
Download Episode 446 (mp3, 0.4MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 445: Statins ineffective for primary prevention in patients 75 years or older without diabetes
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Statins ineffective for primary prevention in patients 75 years or older without diabetes"
Download Episode 445 (mp3, 0.6MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 444: Lorcaserin is safe, but only modestly effective (6 pounds greater weight loss than placebo)
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Lorcaserin is safe, but only modestly effective (6 pounds greater weight loss than placebo)"
Download Episode 444 (mp3, 0.6MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 443: Guideline, with no evidence, suggests annual screening for urinary incontinence in women
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Guideline, with no evidence, suggests annual screening for urinary incontinence in women"
Download Episode 443 (mp3, 0.7MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 442: Gabapentin and pregabalin not effective for low back pain with or without radiculopathy
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Gabapentin and pregabalin not effective for low back pain with or without radiculopathy"
Download Episode 442 (mp3, 0.7MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 441: USPSTF 2018: HPV testing alone every 5 years is acceptable screening in women 30 to 65 years old (A recommendation)
Dr. Ebell and Dr. Wilkes discuss the POEM titled "USPSTF 2018: HPV testing alone every 5 years is acceptable screening in women 30 to 65 years old (A recommendation)"
Download Episode 441 (mp3, 0.5MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 440: Aspirin + high-dose PPI prevents death and progression in patients with Barrett's esophagus (AspECT)
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Aspirin + high-dose PPI prevents death and progression in patients with Barrett's esophagus (AspECT)"
Download Episode 440 (mp3, 0.6MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 439: Decompression surgery no more effective than exercise for shoulder impingement syndrome
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Decompression surgery no more effective than exercise for shoulder impingement syndrome"
Download Episode 439 (mp3, 0.5MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 438: Chronic sinusitis: saline irrigation helps somewhat; steroid doesn't add more benefit
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Chronic sinusitis: saline irrigation helps somewhat; steroid doesn't add more benefit"
Download Episode 438 (mp3, 0.5MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 437: Lower systolic BP during antihypertensive treatment associated with more deaths in the elderly
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Lower systolic BP during antihypertensive treatment associated with more deaths in the elderly"
Download Episode 437 (mp3, 0.5MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 436: What are the most effective drug therapies for hirsutism?
Dr. Ebell and Dr. Wilkes discuss the POEM titled "What are the most effective drug therapies for hirsutism?"
Download Episode 436 (mp3, 0.6MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 435: Stigmatizing language in chart notes creates negative impressions
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Stigmatizing language in chart notes creates negative impressions"
Download Episode 435 (mp3, 0.6MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 434: NPH insulin: fewer episodes of severe hypoglycemia than analogs (Lantus and Levemir) and less than half the cost
Dr. Ebell and Dr. Wilkes discuss the POEM titled "NPH insulin: fewer episodes of severe hypoglycemia than analogs (Lantus and Levemir) and less than half the cost"
Download Episode 434 (mp3, 0.6MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 433: Incidental findings are common with chest CT and MRI of the spine and brain
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Incidental findings are common with chest CT and MRI of the spine and brain"
Download Episode 433 (mp3, 0.5MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 432: Mifepristone pretreatment improves success rate of misoprostol for early pregnancy loss
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Mifepristone pretreatment improves success rate of misoprostol for early pregnancy loss"
Download Episode 432 (mp3, 0.6MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 431: American Academy of Pediatrics guidelines for treating depression in adolescents
Dr. Ebell and Dr. Wilkes discuss the POEM titled "American Academy of Pediatrics guidelines for treating depression in adolescents"
Download Episode 431 (mp3, 0.7MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 430: Febuxostat increases all-cause and CV mortality compared with allopurinol
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Febuxostat increases all-cause and CV mortality compared with allopurinol"
Download Episode 430 (mp3, 0.6MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 428: Cannabinoids somewhat helpful for nausea, maybe helpful for spasticity, probably not helpful for non-neuropathic pain
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Cannabinoids somewhat helpful for nausea, maybe helpful for spasticity, probably not helpful for non-neuropathic pain"
Download Episode 428 (mp3, 0.7MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 427: Five-day nitrofurantoin superior to single-dose fosfomycin for women with uncomplicated UTI
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Five-day nitrofurantoin superior to single-dose fosfomycin for women with uncomplicated UTI"
Download Episode 427 (mp3, 0.5MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 426: American Academy of Pediatrics guidelines for treating depression in adolescents
Dr. Ebell and Dr. Wilkes discuss the POEM titled "American Academy of Pediatrics guidelines for treating depression in adolescents"
Download Episode 426 (mp3, 0.7MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 425: Nonopioids equivalent to opioids for severe chronic back, hip, or knee pain with fewer adverse outcomes
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Nonopioids equivalent to opioids for severe chronic back, hip, or knee pain with fewer adverse outcomes"
Download Episode 425 (mp3, 0.8MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 424: HPV testing better than cytology for women vaccinated against HPV
Dr. Ebell and Dr. Wilkes discuss the POEM titled "HPV testing better than cytology for women vaccinated against HPV"
Download Episode 424 (mp3, 0.6MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 423: Systolic blood pressure at least 140 mm Hg best place to begin treatment
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Systolic blood pressure at least 140 mm Hg best place to begin treatment"
Download Episode 423 (mp3, 0.6MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 422: Long-acting muscarinic antagonists + inhaled steroids = long-acting B-agonists + inhaled steroids
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Long-acting muscarinic antagonists + inhaled steroids = long-acting B-agonists + inhaled steroids"
Download Episode 422 (mp3, 0.5MB)
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Episode 421: Single maintenance and reliever therapy more effective than inhaled steroids and short-acting B-agonists for asthma (SMART)
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Single maintenance and reliever therapy more effective than inhaled steroids and short-acting B-agonists for asthma (SMART)"
Download Episode 421 (mp3, 0.5MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 420: Drugs for chronic idiopathic constipation are similarly effective
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Drugs for chronic idiopathic constipation are similarly effective"
Download Episode 420 (mp3, 3.1MB)
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Episode 419: Determining what matters to patients with multiple chronic diseases
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Determining what matters to patients with multiple chronic diseases"
Download Episode 419 (mp3, 2.9MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 418: Statins effective for LDL 190 mg/dL or higher, regardless of risk level
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Statins effective for LDL 190 mg/dL or higher, regardless of risk level"
Download Episode 418 (mp3, 3.5MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 417: Short courses of antibiotics as effective as longer courses for outpatient infections
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Short courses of antibiotics as effective as longer courses for outpatient infections"
Download Episode 417 (mp3, 3MB)
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Episode 416: FIT more acceptable with better detection rate than gFOBT for colorectal cancer screening
Dr. Ebell and Dr. Wilkes discuss the POEM titled "FIT more acceptable with better detection rate than gFOBT for colorectal cancer screening"
Download Episode 416 (mp3, 4.4MB)
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Episode 415: Clinical diagnosis of Lyme disease frequently misses the bull’s-eye
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Clinical diagnosis of Lyme disease frequently misses the bull’s-eye"
Download Episode 415 (mp3, 5.9MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 414: Early PT for acute low back pain is cost-effective, but gain in quality of life is likely too small to notice
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Early PT for acute low back pain is cost-effective, but gain in quality of life is likely too small to notice"
Download Episode 414 (mp3, 6.4MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 413: Colorectal cancer screening recommendations for average-risk and high-risk persons from US GI societies
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Colorectal cancer screening recommendations for average-risk and high-risk persons from US GI societies"
Download Episode 413 (mp3, 5.6MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 412: Broad-spectrum antibiotics increase adverse events in children with acute respiratory infections with minimal benefit
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Broad-spectrum antibiotics increase adverse events in children with acute respiratory infections with minimal benefit "
Download Episode 412 (mp3, 0.6MB)
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Episode 411: ACC/AHA guidelines take more aggressive, less evidence-based approach to hypertension management
Dr. Ebell and Dr. Wilkes discuss the POEM titled "ACC/AHA guidelines take more aggressive, less evidence-based approach to hypertension management"
Download Episode 411 (mp3, 0.9MB)
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Episode 410: High-sensitivity troponin I of less than 5 ng/L has negative predictive value of 99.9% for cardiac death at 1 year
Dr. Ebell and Dr. Wilkes discuss the POEM titled "High-sensitivity troponin I of less than 5 ng/L has negative predictive value of 99.9% for cardiac death at 1 year"
Download Episode 410 (mp3, 0.7MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 409: Ibuprofen + acetaminophen equals opioid + acetaminophen for acute severe extremity pain
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Ibuprofen + acetaminophen equals opioid + acetaminophen for acute severe extremity pain"
Download Episode 409 (mp3, 0.6MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 408: Ibuprofen and morphine provide similar post-op pain relief in kids; ibuprofen has fewer harms
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Ibuprofen and morphine provide similar post-op pain relief in kids; ibuprofen has fewer harms"
Download Episode 408 (mp3, 0.6MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 407: Rivaroxaban + aspirin somewhat better than aspirin alone for tertiary prevention of CVD (COMPASS)
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Rivaroxaban + aspirin somewhat better than aspirin alone for tertiary prevention of CVD (COMPASS)"
Download Episode 407 (mp3, 0.7MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 406: Minimal effect of ERT on sexual function in menopausal women
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Minimal effect of ERT on sexual function in menopausal women"
Download Episode 406 (mp3, 0.6MB)
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Episode 405: No effect on mortality with oxygen therapy in nonhypoxemic patients with suspected MI
Dr. Ebell and Dr. Wilkes discuss the POEM titled "No effect on mortality with oxygen therapy in nonhypoxemic patients with suspected MI"
Download Episode 405 (mp3, 0.8MB)
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Episode 404: Oral steroids not helpful for acute lower respiratory tract infection in nonasthmatic adults
Dr. Ebell and Dr. Wilkes discuss the POEM titled Oral steroids not helpful for acute lower respiratory tract infection in nonasthmatic adults""
Download Episode 404 (mp3, 0.5MB)
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Episode 403: Lorazepam added to haloperidol effective for agitated delirium in end-of-life cancer patients
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Lorazepam added to haloperidol effective for agitated delirium in end-of-life cancer patients"
Download Episode 403 (mp3, 0.6MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 402: Light therapy improves behavioral disturbances, sleep, depression in elderly with cognitive impairment
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Light therapy improves behavioral disturbances, sleep, depression in elderly with cognitive impairment"
Download Episode 402 (mp3, 0.6MB)
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Episode 401: Single-dose oral dexamethasone decreases sore throat pain
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Single-dose oral dexamethasone decreases sore throat pain"
Download Episode 401 (mp3, 0.6MB)
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Episode 400: Longer term biphosphonates and risk of fractures in older women
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Longer term biphosphonates and risk of fractures in older women"
Download Episode 400 (mp3, 0.5MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 399: Intensive BP Control in older pts and effects on renal function
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Intensive BP Control in older pts and effects on renal function"
Download Episode 399 (mp3, 0.4MB)
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Episode 398: Extremely high HDL cholesterol associated with increased mortality in men and women
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Extremely high Density HDL associated with increased mortality"
Download Episode 398 (mp3, 0.5MB)
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Episode 397: Anacetrapib: effects on CV events
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Anacetrapib: effects on CV events"
Download Episode 397 (mp3, 0.6MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 394: Years clinical decision tool decreases CT angiography in patients with suspected PE
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Years clinical decision tool decreases CT angiography in patients with suspected PE"
Download Episode 394 (mp3, 0.7MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 393: Use of mindfulness or self-hypnosis provides immediate pain relief to hospitalized patients
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Use of mindfulness or self-hypnosis provides immediate pain relief to hospitalized patients"
Download Episode 393 (mp3, 8.2MB)
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Episode 392: Treating sleep apnea with positive airway pressure does not reduce adverse CV outcomes or mortality
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Treating sleep apnea with positive airway pressure does not reduce adverse CV outcomes or mortality"
Download Episode 392 (mp3, 0.5MB)
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Episode 391: No mortality benefit and higher costs with early goal-directed therapy for septic shock
Dr. Ebell and Dr. Wilkes discuss the POEM titled "No mortality benefit and higher costs with early goal-directed therapy for septic shock"
Download Episode 391 (mp3, 0.5MB)
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Episode 390: Mite-impermeable covers decreases hospital visits in kids with asthma
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Mite-impermeable covers decreases hospital visits in kids with asthma"
Download Episode 390 (mp3, 0.6MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 389: Steroid vs antihistamine treatment of acute hives
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Steroid vs antihistamine treatment of acute hives"
Download Episode 389 (mp3, 0.5MB)
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Episode 388: Lipid treatment for primary prevention in older adults
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Lipid treatment for primary prevention in older adults"
Download Episode 388 (mp3, 5.8MB)
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Episode 387: Intra articular knee injections of steroids
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Steroid injections ineffective for knee osteoarthritis"
Download Episode 387 (mp3, 0.4MB)
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Episode 386: Aerobic or resistance exercise in elderly people
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Combination of resistance and aerobic exercise best for obese elderly persons"
Download Episode 386 (mp3, 0.4MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 385: Addition of trimethoprim sulfamethoxazole to cephalexin for cellulitis
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Addition of trimethoprim sulfamethoxazole to cephalexin for cellulitis"
Download Episode 385 (mp3, 5.9MB)
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Episode 384: The Quick Wee method to collect urine in infants
Dr. Ebell and Dr. Wilkes discuss the POEM titled "The Quick Wee method to collect urine in infants"
Download Episode 384 (mp3, 0.3MB)
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Episode 383: Risk of ASD, ADHD, or SGA with first trimester antidepressant use
Dr. Ebell and Dr. Wilkes discuss the POEM titled "No increased risk of ASD, ADHD, or SGA with first trimester antidepressant use"
Download Episode 383 (mp3, 0.5MB)
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Episode 382: Pregabalin for sciatica pain
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Pregabalin for sciatica pain"
Download Episode 382 (mp3, 0.4MB)
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Episode 381: Ketorolac in treatment of acute pain
Dr. Ebell and Dr. Wilkes discuss the POEM titled "No added benefit with higher doses of ketorolac for treatment of acute pain in the ED"
Download Episode 381 (mp3, 0.5MB)
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Episode 380: Dexamethasone may reduce sore throat symptoms in adults
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Dexamethasone may reduce sore throat symptoms in adults"
Download Episode 380 (mp3, 0.5MB)
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Episode 379: Benefits and Harms of screening pelvic exams in symptomatic women
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Benefits and Harms of screening pelvic exams in symptomatic women"
Download Episode 379 (mp3, 0.7MB)
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Episode 378: Is Niacin effective to reduce CV events and mortality
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Is Niacin effective to reduce CV events and mortality"
Download Episode 378 (mp3, 0.6MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 377: Is arthroscopy better than nonsurgical treatment for meniscal tears
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Is arthroscopy better than nonsurgical treatment for meniscal tears"
Download Episode 377 (mp3, 0.6MB)
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Episode 376: What can patients expect from CTtests to screen for lung cancer
Dr. Ebell and Dr. Wilkes discuss the POEM titled "What can patients expect from CTtests to screen for lung cancer"
Download Episode 376 (mp3, 0.8MB)
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Episode 375: Safest and most effective extended therapy for VTE
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Safest and most effective extended therapy for VTE"
Download Episode 375 (mp3, 0.6MB)
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Episode 374: Testosterone treatment and cognitive function in older men
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Testosterone tx and cognitive function in older men"
Download Episode 374 (mp3, 0.5MB)
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Episode 373: Mineralocorticoid receptor antagonists in elder patients
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Mineralocorticoid receptor antagonists in elder patients"
Download Episode 373 (mp3, 0.4MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 372: Efficacy and safety of non operative tx for acute appendicitis
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Efficacy and safety of non operative tx for acute appendicitis"
Download Episode 372 (mp3, 0.6MB)
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Episode 371: Comparison of BP measurement on the bare arm.
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Comparison of BP measurement on the bare arm."
Download Episode 371 (mp3, 0.5MB)
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Episode 370: Bariatric surgery vs intensive medical therapy for diabetes
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Bariatric surgery vs intensive medical therapy for diabetes"
Download Episode 370 (mp3, 0.8MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 369: End of Rotation Care Transitions Impact on Mortality
Dr. Ebell and Dr. Wilkes discuss the POEM titled "End of Rotation Care Transitions Impact on Mortality"
Download Episode 369 (mp3, 0.7MB)
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Episode 368: PCI has more benefits and harms than CABG for selected patients with left main coronary disease
Dr. Ebell and Dr. Wilkes discuss the POEM titled "PCI has more benefits and harms than CABG for selected patients with left main coronary disease"
Download Episode 368 (mp3, 6.1MB)
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Episode 367: Repeat cytology within 6 months = colposcopy for younger women with ASCUS or LSIL
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Repeat cytology within 6 months = colposcopy for younger women with ASCUS or LSIL"
Download Episode 367 (mp3, 8.5MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 366: If you give amoxiclav to 6- to 23-month-olds with AOM, 10 days is preferable to 5 days
Dr. Ebell and Dr. Wilkes discuss the POEM titled "If you give amoxiclav to 6- to 23-month-olds with AOM, 10 days is preferable to 5 days"
Download Episode 366 (mp3, 7.3MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 365: Placebo plus message of benefit decreases chronic low back pain
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Placebo plus message of benefit decreases chronic low back pain"
Download Episode 365 (mp3, 5.3MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 364: Vertebroplasty for acute osteoporotic fractures
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Vertebroplasty for acute osteoporotic fractures"
Download Episode 364 (mp3, 6.2MB)
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Episode 363: Why families who resist vaccines should not be banned from medical practices
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Why families who resist vaccines should not be banned from medical practices"
Download Episode 363 (mp3, 7.3MB)
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Episode 362: Screening for dyslipidemia in younger adults
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Screening for dyslipidemia in younger adults"
Download Episode 362 (mp3, 5.7MB)
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Episode 361: Active surveillance of localized prostate cance
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Active surveillance of localized prostate cance"
Download Episode 361 (mp3, 8.2MB)
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Episode 360: Nasal irrigation or steam inhalation for chronic sinus symptoms
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Nasal irrigation or steam inhalation for chronic sinus symptoms"
Download Episode 360 (mp3, 6.2MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 359: Sleep apnea
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Sleep apnea"
Download Episode 359 (mp3, 5.6MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 358: Diabetes in those over 80
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Diabetes in those over 80"
Download Episode 358 (mp3, 7.4MB)
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Episode 357: Acne and diet
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Acne and diet"
Download Episode 357 (mp3, 4.6MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 356: Endometriosis
Dr. Ebell and Dr. Wilkes discuss the POEM titled "CA125 relatively specific for diagnosing endometriosis"
Download Episode 356 (mp3, 6.4MB)
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Episode 355: Renal stone passage
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Tamsulosin beneficial for passage of 5-mm to 10-mm distal ureteral stones"
Download Episode 355 (mp3, 5.1MB)
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Episode 354: Size of the bottle used to feed infants
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Larger bottles associated with greater weight in infant"
Download Episode 354 (mp3, 0.5MB)
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Episode 353: Ruling out infant infection
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Step-by-step approach to ruling out infant infection is accurate"
Download Episode 353 (mp3, 0.5MB)
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Episode 352: Insomnia guideline
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Insomnia guideline"
Download Episode 352 (mp3, 0.6MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 351: Cervical treatment for invasive disease and association with adverse obstetric outcome
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Cervical treatment for invasive disease and association with adverse obstetric outcome"
Download Episode 351 (mp3, 0.5MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 350: Lumbar fusion for chronic lower back pain
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Lumbar fusion for chronic lower back pain"
Download Episode 350 (mp3, 0.4MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 349: Poor outcomes with sulfonylureas in pts with type 2 DM
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Poor outcomes with sulfonylureas in pts with type 2 DM"
Download Episode 349 (mp3, 8MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 348: CBT effective in adolescents with depression
Dr. Ebell and Dr. Wilkes discuss the POEM titled "CBT effective in adolescents with depression"
Download Episode 348 (mp3, 5.5MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 347: Beliefs among men with prostate cancer
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Beliefs among men with prostate cancer"
Download Episode 347 (mp3, 5.5MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 346: Providing patients with the costs of care does not reduce health care spending
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Providing patients with the costs of care does not reduce health care spending"
Download Episode 346 (mp3, 5.8MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 345: Inhaled fluticasone-salmeterol better than fluticasone alone for asthma
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Inhaled fluticasone-salmeterol better than fluticasone alone for asthma"
Download Episode 345 (mp3, 0.6MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 344: Flibanserin ineffective for hypoactive sexual desire disorder in women
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Flibanserin ineffective for hypoactive sexual desire disorder in women"
Download Episode 344 (mp3, 6.9MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 343: Pioglitazone after stroke or TIA
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Pioglitazone after stroke or TIA reduces stroke and MI, but has significant harms as well"
Download Episode 343 (mp3, 3MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 342: Antipsychotics to treat delirium
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Stop using antipsychotics to treat or prevent delirium -- they are no better than placebo"
Download Episode 342 (mp3, 3.2MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 341: Primary care doctors prescribing opiates
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Updated CDC guidelines for opioid prescribing for chronic pain"
Download Episode 341 (mp3, 4.3MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 340: Knee surgery does not reduce catching and locking
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Knee surgery does not reduce knee catching or locking in patients with meniscal tear (FIDELITY)"
Download Episode 340 (mp3, 3.3MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 339: One vs three days of steroids for asthma
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Single-dose dexamethasone = 3 days of steroids in children with acute asthma"
Download Episode 339 (mp3, 2.8MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 338: Do genetic tests change behavior?
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Genetic test results that identify increased risk do not change behavior"
Download Episode 338 (mp3, 4.1MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 337: HTN in diabetes
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Blood pressure goal of 140-150 mmHg best for patients with diabetes"
Download Episode 337 (mp3, 3.1MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 336: Telephone coaching to reduce hospital readmission
Dr. Ebell and Dr. Wilkes discuss the POEM titled "No reduction in re-admissions with telemonitoring, coaching for HF patients (BEAT-HF)"
Download Episode 336 (mp3, 2.9MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 335: Ovarian cancer screening
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Ovarian cancer screening does not improve outcomes (UKCTOCS)"
Download Episode 335 (mp3, 4.3MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 334: Mediterranean diet
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Mediterranean diet produces moderate weight loss"
Download Episode 334 (mp3, 2.5MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 333: Putting lung screening guidelines into practice
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Lung cancer screening requires additional imaging in 40% of patients in real world"
Download Episode 333 (mp3, 4.4MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 332: Tamsulosin for distal stones
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Tamsulosin effective as expulsion therapy for 5-mm to 10-mm distal ureteric stones"
Download Episode 332 (mp3, 2.7MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 331: Signs and symptoms of severe intracranial head injury
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Useful signs and symptoms of severe intracranial injury after minor head trauma"
Download Episode 331 (mp3, 3.2MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 330: Accuracy of high sensitivity troponins
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Low HS-troponin I accurate in identifying patients at low risk of cardiac events"
Download Episode 330 (mp3, 3.1MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 329: Hyaluroniac acid injection in pts with DJD
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Hyaluronic acid = sham injections in patients with knee DJD"
Download Episode 329 (mp3, 3MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 328: Red eye
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Best approaches to physical diagnosis of acute red eye"
Download Episode 328 (mp3, 3.7MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 327: Use of hip xray in hip osteoarthritis
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Little correlation between hip pain and radiographic evidence of osteoarthritis"
Download Episode 327 (mp3, 3.5MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 326: Natural hx of HTN in relation to CV disease
Dr. Ebell and Dr. Wilkes discuss the POEM titled "SBP of 120 instead of 140 in nondiabetic, high-risk elderly leads to significant benefits and some harms (SPRINT)"
Download Episode 326 (mp3, 5.3MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 325: Sliding Scale insulin in hospitalized patients
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Sliding-scale insulin does not improve blood glucose control in hospitalized patients"
Download Episode 325 (mp3, 3.3MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 324: CBT for insomnia
Dr. Ebell and Dr. Wilkes discuss the POEM titled "CBT effective for chronic insomnia"
Download Episode 324 (mp3, 3.6MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 323: Guidelines for lower lipids to prevent CVD
Dr. Ebell and Dr. Wilkes discuss the POEM titled "More nuanced guidelines for lipid lowering to prevent CV disease"
Download Episode 323 (mp3, 4.5MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 322: Perioperative bridging anticoagulation
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Perioperative bridging anticoagulation unhelpful for invasive procedures"
Download Episode 322 (mp3, 4.4MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 321: Routine CT scans for malignancy in unprovoked PE
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Routine CT scans for occult malignancy not useful in patients with unprovoked VTE"
Download Episode 321 (mp3, 3MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 320: Personalizing the experience of death in the ICU
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Personalizing the experience of death in the ICU for all involved"
Download Episode 320 (mp3, 3.4MB)
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Episode 319: Adding sitagliptin for type 2 diabetes
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Adding sitagliptin does not reduce or increase the risk of cardiovascular outcomes"
Download Episode 319 (mp3, 3.9MB)
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Episode 318: Coronary computed tomograph vs stress testing
Dr. Ebell and Dr. Wilkes discuss the POEM titled "CCTA and radionuclide stress testing similar for evaluation of chest pain"
Download Episode 318 (mp3, 2.8MB)
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Episode 317: Mild obstructive sleep apnea
Dr. Ebell and Dr. Wilkes discuss the POEM titled "An oral appliance does not improve sleep in patients with less severe sleep apnea"
Download Episode 317 (mp3, 2.7MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 316: Benefits of treating mild HTN
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Some benefit to treating mild hypertension to prevent stroke, CV deaths, and overall mortality"
Download Episode 316 (mp3, 4.3MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 315: Continuation of warfarin for 18 months after PE
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Continuing warfarin for 18 months after unprovoked PE reduces risk of recurrent VTE"
Download Episode 315 (mp3, 4MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 314: Assessing delirium
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Rapid accurate assessment of delirium in older ED patients"
Download Episode 314 (mp3, 3.6MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 313: Gabapentin vs epidural steroids for radicular pain
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Gabapentin = epidural steroid for radicular pain"
Download Episode 313 (mp3, 3.9MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 312: CT angiogram with suspected CAD
Dr. Ebell and Dr. Wilkes discuss the POEM titled "CT coronary angiography in patients with suspected CAD: no short-term benefit, increased rate of invasive angiography"
Download Episode 312 (mp3, 3.3MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 311: Geriatric Depression
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Citalopram plus methylphenidate better than either alone for geriatric depression"
Download Episode 311 (mp3, 4.7MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 310: Surgery vs PT for spinal stenosis
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Spinal stenosis: physical therapy before surgery"
Download Episode 310 (mp3, 3.2MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 309: Acetaminophen for lower back pain
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Acetaminophen (paracetamol) minimally effective for back pain and osteoarthritis"
Download Episode 309 (mp3, 3.8MB)
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Episode 308: Safety and effectiveness of alirocumab in high risk patients
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Alirocumab has minimal net benefit for patients with hyperlipidemia (ODYSSEY LONG TERM)"
Download Episode 308 (mp3, 6.9MB)
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Episode 307: Adding prednisone to antibiotics in CAP
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Prednisone speeds recovery, shortens stay in patients hospitalized with CAP"
Download Episode 307 (mp3, 3.2MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 306: Bridging anticoagulation
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Bridging anticoagulation in patients with AF associated with more CVEs and bleeding"
Download Episode 306 (mp3, 3.2MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 305: Early imaging of backs in older adults
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Early imaging for low back pain in elderly raises costs without improving quality"
Download Episode 305 (mp3, 4.1MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 304: Quick cardiac assay to rule in or out MI
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Two-hour algorithm to rule in or rule out AMI"
Download Episode 304 (mp3, 3.5MB)
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Episode 303: Prescribed walking vs physical therapy
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Walking program effective for chronic low back pain"
Download Episode 303 (mp3, 3.2MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 302: Dish washing and allergy development
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Hand washing children's dishes associated with fewer allergies"
Download Episode 302 (mp3, 2.5MB)
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Episode 301: Sterile gloves and minor skin sugery
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Sterile gloves not necessary for minor skin surgery"
Download Episode 301 (mp3, 2MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 300: Safety of antidepressants and suicide risk
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Are some antidepressants safer than others regarding suicide risk?"
Download Episode 300 (mp3, 4.2MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 299: Chewing gum to prevent ileus post op
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Chewing gum prevents ileus after colorectal surgery"
Download Episode 299 (mp3, 3.1MB)
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Episode 298: Diabetes guidelines
Dr. Ebell and Dr. Wilkes discuss two POEMs related to diabetes
Download Episode 298 (mp3, 4.1MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 297: 9 valent HPV vaccine vs quadravalent
Dr. Ebell and Dr. Wilkes discuss the POEM titled "9-valent HPV vaccine offers only small advantage over quadrivalent vaccine"
Download Episode 297 (mp3, 4.2MB)
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Episode 296: Prolonged dual antiplatelet therapy after stent
Dr. Ebell and Dr. Wilkes discuss the POEM titled "More than 1 year of dual-antiplatelet therapy after stent more harmful than beneficial (ARCTIC-Interruption)"
Download Episode 296 (mp3, 3.7MB)
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Episode 295: Frequency of harms from amoxicillin
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Amoxiclav causes diarrhea in 1 of 8 persons who take it"
Download Episode 295 (mp3, 3.3MB)
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Episode 294: ASA for VTE after anticoagulation
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Patients with initial unprovoked DVT or PE benefit from long-term low-dose aspirin (INSPIRE)"
Download Episode 294 (mp3, 3.5MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 293: Lung CA screening with low dose chest CT
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Lung cancer screening is cost effective, but only if done correctly"
Download Episode 293 (mp3, 5.6MB)
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Episode 292: Effect of treatment of CIN on fertility/pregnancy
Dr. Ebell and Dr. Wilkes discuss the POEM titled "CIN treatment may increase miscarriages but does not affect fertility"
Download Episode 292 (mp3, 3.4MB)
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Episode 291: Decision support tools and EMR
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Clinical decision support linked to EMRs doesn't decrease mortality"
Download Episode 291 (mp3, 3.1MB)
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Episode 290: Beta blocker tx after MI
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Post-MI beta-blockers do not decrease mortality"
Download Episode 290 (mp3, 4MB)
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Episode 289: Screening for asymptomatic CAD with tomography
Dr. Ebell and Dr. Wilkes discuss the POEM titled "No benefit to screening with CT angiography for asymptomatic CAD in adults with diabetes"
Download Episode 289 (mp3, 3.4MB)
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Episode 288: Low fat vs low carb diets
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Low-carb diet better than low-fat diet to reduce CV risk factors and cause weight loss"
Download Episode 288 (mp3, 2.1MB)
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Episode 287: Ultrasound vs CT scan for renal stone
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Ultrasound is best initial imaging for suspected kidney stones"
Download Episode 287 (mp3, 3.2MB)
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Episode 286: Planar fasciitis strengthening vs stretching
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Strength training better than stretching for plantar fasciitis"
Download Episode 286 (mp3, 3.2MB)
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Episode 285: Psycho therapy vs antidepressants in adults with IBS
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Antidepressants and psychological therapies are effective for IBS"
Download Episode 285 (mp3, 4.1MB)
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Episode 284: Optimal treatment for acute venous thromboembolism
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Optimal treatment of acute venous thromboembolism"
Download Episode 284 (mp3, 4.2MB)
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Episode 283: Steroid injection vs PT for nontraumatic shoulder pain
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Injection = PT for shoulder impingement"
Download Episode 283 (mp3, 3.7MB)
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Episode 282: High dose vs low dose flu vaccine
Dr. Ebell and Dr. Wilkes discuss the POEM titled "High-dose vaccine reduces clinical flu in elderly compared with standard dose (NNT = 220)"
Download Episode 282 (mp3, 2.7MB)
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Episode 281: Raising HDL
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Increasing HDL level ineffective at decreasing cardiovascular events"
Download Episode 281 (mp3, 2.3MB)
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Episode 280: Mycoplasma pneumonia in kids
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Evidence does not show benefit of treating mycoplasma pneumonia in children"
Download Episode 280 (mp3, 3.1MB)
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Episode 279: Cholesterol and weight gain
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Increased fat and caloric intake in patients on statins"
Download Episode 279 (mp3, 3.2MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 278: Is desmopressin safe and effective?
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Desmopressin effective for treating nocturia in adults"
Download Episode 278 (mp3, 3.7MB)
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Episode 277: Time of day of testing for serum testosterone
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Optimal time of day to measure serum testosterone levels varies with age"
Download Episode 277 (mp3, 3.3MB)
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Episode 276: Bariatric surgery plus intensive medical therapy
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Bariatric surgery plus intensive medical therapy better than medical therapy alone for diabetes (STAMPEDE)"
Download Episode 276 (mp3, 3.3MB)
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Episode 275: Benefits of smoke-free legislation
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Smoke-free legislation associated with better child and perinatal health"
Download Episode 275 (mp3, 3.3MB)
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Episode 274: Azithromycin in pneumonia and cardiovascular events
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Net benefit with azithromycin use in elderly hospitalized patients with pneumonia"
Download Episode 274 (mp3, 4.6MB)
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Episode 273: Macular degeneration and omega 3 fatty acids
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Omega-3 fatty acid supplementation does not decrease CVD-related outcomes"
Download Episode 273 (mp3, 4MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 272: Dual antiplatelet therapy
Dr. Ebell and Dr. Wilkes discuss the POEM titled "No benefit to prolonged dual antiplatelet therapy after drug-eluting stent placement"
Download Episode 272 (mp3, 3.4MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 271: Adenoma detection rates
Dr. Ebell and Dr. Wilkes discuss the POEM titled "High adenoma detection rate during colonoscopy associated with lower incidence of colorectal cancer"
Download Episode 271 (mp3, 3.4MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 270: Cholesterol guidelines and ACA recommendations
Dr. Ebell and Dr. Wilkes discuss the POEM titled "2013 ACC/AHA cholesterol guidelines greatly increase number eligible for statin treatment"
Download Episode 270 (mp3, 3.8MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 269: Guaiac based testing
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Accuracy of fecal DNA and fecal immunochemical test for colorectal cancer detection"
Download Episode 269 (mp3, 5.1MB)
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Episode 268: Common cold and analgesia and steam
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Cold symptoms unaffected by regular analgesic dosing or use of steam"
Download Episode 268 (mp3, 3.9MB)
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Episode 267: Back pain and opioids
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Opioids for chronic back pain: short-term effectiveness, long-term uncertain"
Download Episode 267 (mp3, 3.6MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 266: Colon cancer screening
Dr. Ebell and Dr. Wilkes discuss the POEM titled "IFOBTs moderately sensitive and highly specific for colon cancer"
Download Episode 266 (mp3, 3.2MB)
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Episode 265: Endocrine therapy to prevent breast cancer
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Anastrozole decreases rate of breast cancer in high-risk postmenopausal women (IBIS-II)"
Download Episode 265 (mp3, 1.5MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 264: Lung cancer screening
Dr. Ebell and Dr. Wilkes discuss the POEM titled "USPSTF recommends lung cancer screening for some smokers"
Download Episode 264 (mp3, 3MB)
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Episode 263: Intensive follow-up after colorectal cancer surgery
Dr. Ebell and Dr. Wilkes discuss the POEM titled "No increased survival benefit to intensive follow-up after colorectal cancer surgery"
Download Episode 263 (mp3, 4.4MB)
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Episode 262: Varenicline plus bupropion for tobacco cessation
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Varenicline plus bupropion SR no better than varenicline alone for tobacco cessation"
Download Episode 262 (mp3, 3.3MB)
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Episode 261: Predicting poor prognosis with COPD exacerbation
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Sputum purulence and CRP predict poor prognosis with COPD exacerbation"
Download Episode 261 (mp3, 3.7MB)
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Episode 260: Surgery for partial medial meniscectomy
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Surgery ineffective for non-traumatic partial medial meniscus tear"
Download Episode 260 (mp3, 3.3MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 259: Screening for cervical cancer
Dr. Ebell and Dr. Wilkes discuss the POEM titled "HPV screening every 5 years = Pap smear every 3 years"
Download Episode 259 (mp3, 4.2MB)
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Episode 258: Benefits of nuts
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Nut consumption associated with reduced mortality"
Download Episode 258 (mp3, 3.8MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 257: Renal Artery Stenting
Dr. Ebell and Dr. Wilkes discuss the POEM titled "No benefit to addition of stenting for treatment of atherosclerotic renal artery stenosis"
Download Episode 257 (mp3, 3.4MB)
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Episode 256: Obesity medications
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Long-term results of drug treatment for obesity"
Download Episode 256 (mp3, 2.9MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 255: Muscle training for incontinence
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Pelvic floor muscle training does not reduce postpartum urinary incontinence"
Download Episode 255 (mp3, 2.8MB)
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Episode 254: Elderly preferences for screening tests
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Elders want a say in when to stop cancer screenings"
Download Episode 254 (mp3, 3.4MB)
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Episode 253: Flu and cardiac risk
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Flu vaccine reduces risk of adverse CV events in high-risk patients"
Download Episode 253 (mp3, 2.9MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 252: Effectiveness of STI education
Dr. Ebell and Dr. Wilkes discuss the POEM titled "STI counseling with HIV testing does not reduce subsequent STI acquisition"
Download Episode 252 (mp3, 3.9MB)
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Episode 251: Pericarditis
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Colchicine effective for first episode of acute pericarditis"
Download Episode 251 (mp3, 3.4MB)
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Episode 250: Acute bronchitis
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Amox/clav or ibuprofen no better than placebo for acute bronchitis"
Download Episode 250 (mp3, 4.3MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 249: Scoliosis bracing
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Impact of bracing in adolescents with idiopathic scoliosis (BRAIST)"
Download Episode 249 (mp3, 4.4MB)
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Episode 248: What happens with a negative strep test
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Confirmation of negative strep result may be unnecessary in adults"
Download Episode 248 (mp3, 3.5MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 247: Vitamin D and systolic hypertension
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Vitamin D does not affect isolated systolic hypertension"
Download Episode 247 (mp3, 3.1MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 246: Does metformin affect CV events
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Fewer deaths/strokes/revascularizations with metformin than glipizide."
Download Episode 246 (mp3, 2.2MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 245: Finasteride and prevention of prostate cancer
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Finasteride prevents low-grade prostate cancers, but does not reduce mortality"
Download Episode 245 (mp3, 3.5MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 244: Effect of vitamin D on depressive symptoms
Dr. Ebell and Dr. Wilkes discuss the POEM titled "No effect of vitamin D on depressive symptoms"
Download Episode 244 (mp3, 3.3MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 243: Exercise in older people with depression
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Exercise effective for depression in older people"
Download Episode 243 (mp3, 2.9MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 242: Exercise and weight loss in diabetes
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Intensive lifestyle intervention fails to improve patient-oriented outcomes in obese diabetics"
Download Episode 242 (mp3, 4MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 241: Criteria for dx of acute bacterial sinusitis in kids
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Sinusitis Guidelines 2013 -- American Academy of Pediatrics"
Download Episode 241 (mp3, 3.5MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 240: Clopidogrel plus ASA in TIA
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Clopidogrel + 21 days ASA superior to ASA alone within first 24 hrs of TIA or minor stroke"
Download Episode 240 (mp3, 3.5MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 239: ASA vs LMWH after THA
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Aspirin as safe and effective as LMWH for extended thromboprophylaxis after THA"
Download Episode 239 (mp3, 3MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 238: Prolotherapy for knee
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Dextrose prolotherapy decreases pain and stiffness in knee DJD"
Download Episode 238 (mp3, 3.7MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 237: Systemic Glucocorticoids for COPD
Dr. Ebell and Dr. Wilkes discuss the POEM titled "5-day steroid treatment effective for acute COPD exacerbation"
Download Episode 237 (mp3, 2.7MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 236: Treatments for flu
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Oseltamivir marginally decreases flu duration; no decrease in flu complications"
Download Episode 236 (mp3, 5.1MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 235: Warfarin vs bridging heparin
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Continued warfarin better than bridging therapy for pacemaker or defibrillator surgery (BRUISE CONTROL)"
Download Episode 235 (mp3, 3.6MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 234: n3 fatty acids to prevent CVD
Dr. Ebell and Dr. Wilkes discuss the POEM titled "n-3 fatty acids do not prevent cardiovascular events in high-risk patients"
Download Episode 234 (mp3, 3.4MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 233: ACL ligament tear - rehab vs delayed reconstuction
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Knee injury: rehab = ACL reconstruction for many young adults"
Download Episode 233 (mp3, 3MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 232: Chlorthalidone vs HCTZ for HTN in older adults
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Same benefit with equivalent chlorthalidone and HCTZ"
Download Episode 232 (mp3, 2.5MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 231: Mediterranean diet vs low fat diet
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Mediterranean diet reduces cardiovascular events (PREDIMED)"
Download Episode 231 (mp3, 2.6MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 230: Top ten strategies to improve patient safety
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Top 10 strategies to improve patient safety"
Download Episode 230 (mp3, 2.4MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 229: Best interval for fecal testing to screen for colon cancer
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Colorectal neoplasia yield similar for FIT every 1, 2 or 3 years"
Download Episode 229 (mp3, 3.9MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 228: Dabifatran or warfarin in VT
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Extended use of dabigatran no better than warfarin for high-risk pts after VTE; no net benefit vs placebo for avg-risk pts"
Download Episode 228 (mp3, 4.7MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 227: Lateral epicondylitis
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Steroid injection for lateral epicondylitis worse than saline after 1 year"
Download Episode 227 (mp3, 3.7MB)
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Episode 226: Ramipril to improve walking
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Ramipril increases pain-free walking time in patients with intermittent claudication"
Download Episode 226 (mp3, 3.1MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 225: Duration of Cough
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Mean duration of cough is 18 days; patients expect about 1 week"
Download Episode 225 (mp3, 2.9MB)
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Episode 224: Smoking cessation in children and adolescents
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Smoking prevention counseling works in adolescents, cessation efforts don't"
Download Episode 224 (mp3, 3.9MB)
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Episode 223: Self taken swabs and STIs
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Self-taken swabs improve gonorrhea and chlamydia test accuracy"
Download Episode 223 (mp3, 2.8MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 222: Guidelines for patients with multiple conditions
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Guidelines not helpful in patients with multiple conditions"
Download Episode 222 (mp3, 3.3MB)
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Episode 221: Sleeping policemen to diagnose appendicitis
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Speed bumps can aid in the diagnosis of acute appendicitis"
Download Episode 221 (mp3, 3.2MB)
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Episode 220: Vitamin D and calcium to prevent cognitive decline
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Vitamin D + calcium = placebo for cognitive decline (WHI)"
Download Episode 220 (mp3, 3.3MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 219: Special catheters to reduce UTIs
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Rate of UTIs in pts using special catheters = rate using standard catheters"
Download Episode 219 (mp3, 2.8MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 218: ASA after anticoagulation to prevent VTE
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Aspirin following anticoagulation therapy prevents recurrent VTE (ASPIRE)"
Download Episode 218 (mp3, 2.6MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 217: Multivitamins and cancer in men
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Daily multivitamins have minimal, if any, effect on preventing cancer in men and do not affect mortality"
Download Episode 217 (mp3, 3.7MB)
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Episode 216: Beta blockers and MI
Dr. Ebell and Dr. Wilkes discuss the POEM titled "B-blockers not associated with less morbidity/mortality in adults with CAD or CAD risk factors"
Download Episode 216 (mp3, 4MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 215: Zoledronic acid and fractures in men
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Zoledronic acid reduces asymptomatic fractures but not clinical ones in men"
Download Episode 215 (mp3, 3.8MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 214: Tiotropium and asthma
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Adding tiotropium of little benefit in asthma"
Download Episode 214 (mp3, 3MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 213: Discontinuing warfarin after GI bleeds
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Discontinuing warfarin therapy indefinitely after GI bleeding assoc with worse outcomes"
Download Episode 213 (mp3, 2.8MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 212: Abnormal MRI findings of normal knees
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Knee findings on MRI are common in older adults with or without pain"
Download Episode 212 (mp3, 2.8MB)
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Episode 211: Omega-3 fatty acids and CVD
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Omega-3 fatty acid supplementation does not reduce mortality or CVD events"
Download Episode 211 (mp3, 3.6MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 210: Bridging Heparin during surgery
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Bridging heparin during surgery not supported by evidence"
Download Episode 210 (mp3, 3.5MB)
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Episode 209: Honey and Cough
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Honey improves nocturnal cough in children"
Download Episode 209 (mp3, 2.1MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 208: Reducing length of stay in comm acquired pneumonia
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Implementation of 3-step pathway reduces LOS for hospitalized pneumonia patients"
Download Episode 208 (mp3, 3.8MB)
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Episode 207: Flexible sig to reduce CRC
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Flex sig reduces incidence and mortality of colorectal cancer"
Download Episode 207 (mp3, 3.3MB)
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Episode 206: Lipid related markers to predict CV events
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Lipid-related markers slightly improve CVD prediction"
Download Episode 206 (mp3, 3.3MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 205: Strep throat decision rules
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Rules for strep throat validated"
Download Episode 205 (mp3, 3MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 204: Urinary incontinence
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Less than 20% of patients with urinary incontinence benefit from Rx therapy"
Download Episode 204 (mp3, 3MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 203: Antibiotics for appendicitis
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Conservative therapy with antibiotics is an option for early uncomplicated acute appendicitis"
Download Episode 203 (mp3, 3.6MB)
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Episode 202: Type 2 DM - less strict control
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Guidelines for type 2 diabetes: less strict control"
Download Episode 202 (mp3, 4.1MB)
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Episode 201: Botulinum treatment for migraines
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Botulinum toxin A useful for chronic daily headaches and chronic migraines"
Download Episode 201 (mp3, 3.5MB)
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Episode 200: Nocturnal leg cramps
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Bedtime leg stretching reduces frequency and severity of nocturnal leg cramps"
Download Episode 200 (mp3, 3.3MB)
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Episode 199: Closure of patent foramen ovale
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Closure of PFO similar to medical therapy for cryptogenic stroke or TIA"
Download Episode 199 (mp3, 3.8MB)
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Episode 198: Medication after stent placement
Dr. Ebell and Dr. Wilkes discuss the POEM titled "24 months of clopidogrel after stent no better than 6 months"
Download Episode 198 (mp3, 2.7MB)
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Episode 197: Prodaxa to prevent MI
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Dabigatran associated with increased risk of coronary events"
Download Episode 197 (mp3, 2.6MB)
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Episode 196: Antibiotics for uncomplicated diverticulitis
Dr. Ebell and Dr. Wilkes discuss the POEM titled "IV abx = IV fluids for acute uncomplicated diverticulitis (AVOD)"
Download Episode 196 (mp3, 3.8MB)
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Episode 195: Home monitoring of blood glucose in type 2 DM
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Home glucose monitoring does not affect control in diabetes not treated with insulin"
Download Episode 195 (mp3, 3.5MB)
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Episode 194: Best interval for repeat BMD testing
Dr. Ebell and Dr. Wilkes discuss the POEM titled "BMD screening every 15 years for low-risk women"
Download Episode 194 (mp3, 3.9MB)
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Episode 193: Screening asymptomatic men for prostate cancer
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Prostate cancer screening: no mortality benefit after 13 years of follow-up (PLCO)"
Download Episode 193 (mp3, 3.7MB)
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Episode 192: Decision rules for suspected influenza
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Validated clinical decision rule to guide management for patients with suspected influenza"
Download Episode 192 (mp3, 3.7MB)
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Episode 191: Pregnant women and at-home birth
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Home = birth center = OB unit for pregnant women at low risk"
Download Episode 191 (mp3, 3.2MB)
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Episode 190: Aspirin and CVD
Dr. Ebell and Dr. Wilkes discuss the POEM titled "ASA: not for primary prevention"
Download Episode 190 (mp3, 3.3MB)
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Episode 189: Steroids and eustachian tube dysfunction
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Nasal steroids ineffective for ET dysfunction"
Download Episode 189 (mp3, 2.8MB)
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Episode 188: Breast cancer screening
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Breast cancer screening benefits overrated"
Download Episode 188 (mp3, 4MB)
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Episode 187: H pylori eradication vs placebo
Dr. Ebell and Dr. Wilkes discuss the POEM titled "H. pylori eradication decreases functional dyspepsia symptoms (HEROES)"
Download Episode 187 (mp3, 3.3MB)
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Episode 186: Niacin in patients on statins
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Niacin not effective in CAD with low HDL cholesterol (AIM-HIGH)"
Download Episode 186 (mp3, 3.4MB)
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Episode 185: Asymptomatic gallstones
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Asymptomatic gallstones rarely lead to cholecystectomy & may go away"
Download Episode 185 (mp3, 2.9MB)
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Episode 184: ADHD and heart disease
Dr. Ebell and Dr. Wilkes discuss the POEM titled "ADHD drugs do not increase serious CV events in children and young adults"
Download Episode 184 (mp3, 3MB)
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Episode 183: High sensitivity troponins to rule out MI
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Negative high-sensitivity troponin rules out AMI"
Download Episode 183 (mp3, 3.3MB)
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Episode 182: VTE prophylaxis in medical and stroke patients
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Universal VTE prophylaxis not recommended for hospitalized medical and stroke patients"
Download Episode 182 (mp3, 3MB)
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Episode 181: Weight loss and coaches
Dr. Ebell and Dr. Wilkes discuss two POEMs related to weight loss
Download Episode 181 (mp3, 4.5MB)
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Episode 180: Vitamin E and prostate cancer
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Vitamin E supplementation increases risk of prostate cancer"
Download Episode 180 (mp3, 3.1MB)
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Episode 179: False positive mammograms
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Screening for breast cancer: False-positive rates 60% over 10 years"
Download Episode 179 (mp3, 2.9MB)
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Episode 178: Barrett's esophagus
Dr. Ebell and Dr. Wilkes discuss two POEMs relating to Barrett's esophagus
Download Episode 178 (mp3, 3.5MB)
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Episode 177: Alcohol consumption during pregnancy
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Dose-response relationship of alcohol in adverse pregnancy outcomes"
Download Episode 177 (mp3, 3.1MB)
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Episode 176: Steroid or saline for lumbar radiculopathy
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Steroid or saline injection ineffective for lumbar radiculopathy"
Download Episode 176 (mp3, 2.9MB)
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Episode 175: Does adenoidectomy decrease infection?
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Adenoidectomy does not decrease respiratory tract infections in children"
Download Episode 175 (mp3, 3.9MB)
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Episode 174: High dose saw palmetto
Dr. Ebell and Dr. Wilkes discuss the POEM titled "High-dose saw palmetto no better than placebo for BPH symptoms"
Download Episode 174 (mp3, 2.5MB)
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Episode 173: Cytisine to help patients quit smoking
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Cytisine is inexpensive, safe, and modestly effective for smoking cessation"
Download Episode 173 (mp3, 3.3MB)
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Episode 172: Dabigatran vs warfarin in AF
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Dabigatran cost-effective for AF prophylaxis in some patients, not others"
Download Episode 172 (mp3, 5.3MB)
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Episode 171: Massage and lower back pain
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Massage improves function in patients with chronic low back pain"
Download Episode 171 (mp3, 3.2MB)
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Episode 170: Neseritide and acute heart failure
Dr. Ebell and Dr. Wilkes discuss the POEM titled "No benefit of nesiritide for acute heart failure (ASCEND-HF)"
Download Episode 170 (mp3, 3.8MB)
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Episode 169: Placebo and albuterol
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Placebo or sham interventions strongly affect subjective outcome measures"
Download Episode 169 (mp3, 3.1MB)
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Episode 168: Identifying children with serious respiratory
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Symptoms poorly predict kids with serious respiratory illness"
Download Episode 168 (mp3, 3.4MB)
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Episode 167: Symptom detected early prostate cancer
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Treatment for symptom-detected early prostate CA effective in pts younger than 65"
Download Episode 167 (mp3, 3.7MB)
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Episode 166: Leukotriene inhibitors first line or add on
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Pragmatic primary care trial finds LTI similarly effective as inhaled steroid, LABA"
Download Episode 166 (mp3, 3.9MB)
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Episode 165: Vitamin D supplements for mental health
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Annual Vitamin D supplementation does not improve mental well-being"
Download Episode 165 (mp3, 3.5MB)
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Episode 164: Autism medications
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Autistic disorder symptom treatments have limited evidence"
Download Episode 164 (mp3, 4.8MB)
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Episode 163: Ultrasound and wound abscesses
Dr. Ebell and Dr. Wilkes discuss the POEM titled "US-guided needle aspiration ineffective for treatment of skin abscesses"
Download Episode 163 (mp3, 3.7MB)
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Episode 162: Fatty liver disease in children
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Vitamin E and metformin do not reduce liver enzyme levels in pediatric nonalcoholic fatty liver disease"
Download Episode 162 (mp3, 3.1MB)
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Episode 161: DVT - dalteparin vs. heparin
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Dalteparin = unfractionated heparin for ICU DVT prophylaxis"
Download Episode 161 (mp3, 2.4MB)
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Episode 160: Antidepressants in elderly with dementia
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Antidepressants of uncertain effectiveness in patients with depression + dementia"
Download Episode 160 (mp3, 3.4MB)
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Episode 159: Optimal use of loop diuretics in heart failure
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Bolus loop diuretics = continuous infusion in treatment of CHF (DOSE trial)"
Download Episode 159 (mp3, 2.6MB)
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Episode 158: Acyclovir plus hydrocortisone for herpes
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Topical acyclovir plus hydrocortisone superior to acyclovir alone for recurrent herpes labialis"
Download Episode 158 (mp3, 3.4MB)
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Episode 157: Knuckle cracking, high calorie suppl. in demented
Dr. Ebell and Dr. Wilkes discuss two POEMs related to knuckle cracking and elderly patients with dementia
Download Episode 157 (mp3, 3MB)
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Episode 156: Anti hypertensives for secondary prevention of CVD
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Antihypertensive therapy beneficial for patients with BP < 140/90 and history of CVD"
Download Episode 156 (mp3, 3.1MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 155: Echinacea and colds
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Echinacea is ineffective for reducing cold symptoms"
Download Episode 155 (mp3, 3.5MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 154: Signs and symptoms of spinal stenosis
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Useful signs and symptoms of lumbar spinal stenosis"
Download Episode 154 (mp3, 3.4MB)
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Episode 153: Treatment for nocturia
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Oral desmopressin effective for nocturnal polyuria in men with BPH"
Download Episode 153 (mp3, 3.9MB)
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Episode 152: Preventing bedsores
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Skin protection wheelchair cushions better than standard foam cushions in preventing pressure ulcers"
Download Episode 152 (mp3, 2.4MB)
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Episode 151: Enuresis alarm
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Enuresis alarm and desmopressin initially equal, but better long-term success with alarm"
Download Episode 151 (mp3, 3.2MB)
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Episode 150: Vitamin D's dubious benefits
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Limited evidence of benefits of vitamin D supplementation"
Download Episode 150 (mp3, 4.9MB)
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Episode 149: Prostate cancer screening
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Ask-tell-ask approach to discussing prostate cancer screening"
Download Episode 149 (mp3, 2.8MB)
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Episode 148: Statins and cardiac events
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Statin therapy decreases cardiac events"
Download Episode 148 (mp3, 4.1MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 147: Acupuncture and shoulder pain
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Acupuncture effective for chronic shoulder pain"
Download Episode 147 (mp3, 4.5MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 146: Pneumococcal urine testing
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Urinary antigen test useful for diagnosis of pneumococcal pneumonia"
Download Episode 146 (mp3, 3MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 145: Prevention of atrial fib
Dr. Ebell and Dr. Wilkes discuss the POEM titled "ARBs & ACE inhibitors prevent A fib"
Download Episode 145 (mp3, 3.7MB)
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Episode 144: Poorly controlled asthma
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Tiotropium added to steroids is effective in poorly controlled adult asthmatics"
Download Episode 144 (mp3, 3MB)
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Episode 143: Nosocomial pneumonia
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Linezolid no better than vancomycin for treatment of nosocomial pneumonia"
Download Episode 143 (mp3, 3.6MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 142: Lipid lowering in those 80
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Limited data to guide lipid lowering in octogenarians"
Download Episode 142 (mp3, 3.7MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 141: Superficial vein thrombosis
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Fondaparinux effective for superficial thrombosis but at very high cost"
Download Episode 141 (mp3, 3.9MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 140: Prediction rules for CAD
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Clinical prediction rule accurate for primary care chest pain"
Download Episode 140 (mp3, 3.8MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 139: Probiotics and gut flora
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Probiotic decreases colicky crying"
Download Episode 139 (mp3, 4.3MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 138: Osteoarthritis
Dr. Ebell and Dr. Wilkes discuss the POEM titled "NSAID = glucosamine = chondroitin = placebo for knee OA"
Download Episode 138 (mp3, 3.9MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 137: PSA screening
Dr. Ebell and Dr. Wilkes discuss the POEM titled "PSA screening does not decrease mortality"
Download Episode 137 (mp3, 4.5MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 136: Tight glucose control in the ICU
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Tight glycemic control in ICU is harmful"
Download Episode 136 (mp3, 2.6MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 135: Prochlorperazine vs sumatriptan for migraines
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Acute migraine: prochlorperazine better than sumatriptan"
Download Episode 135 (mp3, 3.8MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 134: Use of antibiotics for abcesses
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Placebo = antibiotics for skin abscesses in children"
Download Episode 134 (mp3, 4.2MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 133: Steroid use in COPD
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Low-dose oral = high-dose IV steroids for initial treatment of acute COPD exacerbation"
Download Episode 133 (mp3, 4.3MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 132: Clopidogrel 12 mos beyond stent placement
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Clopidogrel beyond 12 months after stent implantation doesn't improve outcomes"
Download Episode 132 (mp3, 3.5MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 131: Acute neck-back pain: heat pad vs cold pack
Dr. Ebell and Dr. Wilkes discuss the POEM titled "No difference between heating pad or cold pack for acute neck/back strain"
Download Episode 131 (mp3, 4.2MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 130: Male infertility - clomiphene + vit E
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Clomiphene + vitamin E for male infertility"
Download Episode 130 (mp3, 3.1MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 129: Low dose colchicine
Dr. Ebell and Dr. Wilkes discuss the POEM titled "In acute gout, low-dose colchicine = high dose, but with fewer side effects (AGREE)"
Download Episode 129 (mp3, 4.1MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 128: Vitamin B and diabetic nephropathy
Dr. Ebell and Dr. Wilkes discuss the POEM titled "High-dose B-vitamins harmful to patients with diabetic nephropathy"
Download Episode 128 (mp3, 3MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 127: BP reduction in type 2 DM
Dr. Ebell and Dr. Wilkes discuss the POEM titled "BP target of 120 no better than 140 in T2DM (ACCORD)"
Download Episode 127 (mp3, 3.7MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 126: Cholesterol reduction in type 2 DM
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Statin + fenofibrate no better than statin alone in T2DM (ACCORD)"
Download Episode 126 (mp3, 3.6MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 125: Serious infections in kids
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Clinical diagnosis of serious infection in children is difficult"
Download Episode 125 (mp3, 3.9MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 124: Pneumonia vaccine in nursing homes
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Pneumonia vaccine effective in nursing homes"
Download Episode 124 (mp3, 2.9MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 123: BNP monitoring to improve survival
Dr. Ebell and Dr. Wilkes discuss the POEM titled "BNP monitoring + protocol improves HF outcomes"
Download Episode 123 (mp3, 3.5MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 122: Adhesive capsulitis treatment
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Intra-articular more effective than oral steroids for adhesive capsulitis"
Download Episode 122 (mp3, 3.1MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 121: Balance training to prevent sports injuries
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Balance/neuromuscular training decreases sports injuries"
Download Episode 121 (mp3, 2.6MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 120: Management options for UTI
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Poor research quality for newborn hearing testing, screening, and treatment"
Download Episode 120 (mp3, 3.5MB)
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Episode 119: J-shaped curve for glycemic control
Dr. Ebell and Dr. Wilkes discuss the POEM titled "J-shaped survival curve for glycemic control in patients with type 2 DM"
Download Episode 119 (mp3, 3.4MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 118: Blood glucose self-monitoring
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Blood glucose self-monitoring not cost-effective in T2DM patients not taking insulin"
Download Episode 118 (mp3, 3MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 117: ACE vs ARB in patients with ischemic heart disease
Dr. Ebell and Dr. Wilkes discuss the POEM titled "ACE inhibitor preferred over ARB in patients with ischemic heart disease"
Download Episode 117 (mp3, 3.1MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 116: BNP guided therapy
Dr. Ebell and Dr. Wilkes discuss the POEM titled "BNP-guided therapy decreases heart failure mortality (BATTLESCARRED)"
Download Episode 116 (mp3, 2.9MB)
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Episode 115: ASA benefits in people with diabetes
Dr. Ebell and Dr. Wilkes discuss the POEM titled "ASA of limited benefit in patients with diabetes"
Download Episode 115 (mp3, 2.9MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 114: BMI and mortality risk in elderly
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Elderly with higher BMI have lower mortality risk"
Download Episode 114 (mp3, 3.1MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 113: Metformin vs lifestyle for IGT
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Lifestyle better than metformin for delaying DM in patients with IGT (DPPOS)"
Download Episode 113 (mp3, 3.4MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 112: Chemo prevention for high risk breast cancer
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Preventing breast cancer effective in postmenopausal women"
Download Episode 112 (mp3, 2.7MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 111: Screening with mammograms
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Small benefit to breast cancer screening for most women"
Download Episode 111 (mp3, 4MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 110: Self breast exam
Dr. Ebell and Dr. Wilkes discuss the POEM titled "USPSTF: No routine mammography for women younger than 50 years"
Download Episode 110 (mp3, 3.7MB)
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Episode 109: Longevity in nursing homes
Dr. Ebell and Dr. Wilkes discuss two POEMs addressing longevity in nursing homes
Download Episode 109 (mp3, 4.7MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 108: Vitamin D and falls in elderly
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Vitamin D, in high doses, prevents falls"
Download Episode 108 (mp3, 3.3MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 107: Minimally invasive radical prostate surgery
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Minimally invasive vs open radical prostatectomy"
Download Episode 107 (mp3, 4.3MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 106: Back pain
Dr. Ebell and Dr. Wilkes discuss the POEM titled "~ 1% of patients with acute back pain in primary care have serious pathology"
Download Episode 106 (mp3, 3MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 105: Face masks to prevent flu
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Surgical mask and N95 respirator similarly effective for preventing influenza"
Download Episode 105 (mp3, 3.5MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 104: Probiotics for cold symptoms
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Probiotics prevent cold symptoms in children"
Download Episode 104 (mp3, 3.2MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 103: Treatment for Bell's Palsy
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Steroids beneficial, but antiviral agents are of uncertain value for Bell palsy"
Download Episode 103 (mp3, 3.9MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 102: Screening for depression
Dr. Ebell and Dr. Wilkes discuss the POEM titled "PCP diagnosis of depression: not very accurate"
Download Episode 102 (mp3, 3.8MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 101: Diagnosis of kidney stones in kids
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Ultrasound may be best first test for detecting renal stones in children"
Download Episode 101 (mp3, 3.6MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 100: Carpal tunnel syndrome
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Surgery and nonsurgical treatment of carpal tunnel give similar outcomes"
Download Episode 100 (mp3, 3.3MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 99: Hormone plus radiation for prostate cancer
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Hormones + radiation decrease mortality compared with radiation in prostate cancer"
Download Episode 99 (mp3, 3.5MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 98: Patent foramen ovale
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Patent foramen ovale not necessarily associated with stroke recurrence"
Download Episode 98 (mp3, 3.3MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 97: Ear infection treatment
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Treatment of AOM leads to subsequent ear infections"
Download Episode 97 (mp3, 2.6MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 96: Diagnosing the acute abdomen
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Ultrasound, followed by CT if negative, best for acute abdomen"
Download Episode 96 (mp3, 3.9MB)
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Episode 95: Mamography and overdiagnosis
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Mammography identifies many women who will not benefit from treatment"
Download Episode 95 (mp3, 4.4MB)
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Episode 94: Risk of ACS with normal EKG
Dr. Ebell and Dr. Wilkes discuss the POEM titled "ACS risk similar with normal ECG performed during presence or absence of chest pain"
Download Episode 94 (mp3, 2.3MB)
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Episode 93: Need to monitor BMD after treatment
Dr. Ebell and Dr. Wilkes discuss the POEM titled "No need to monitor BMD after bisphosphonates started"
Download Episode 93 (mp3, 3.4MB)
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Episode 92: Lower back pain guideline
Dr. Ebell and Dr. Wilkes discuss the POEM titled "NICE guidelines for low back pain"
Download Episode 92 (mp3, 3.4MB)
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Episode 91: Discharge instructions
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Structured discharge instructions reduce hospital use"
Download Episode 91 (mp3, 2.6MB)
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Episode 90: False positives
Dr. Ebell and Dr. Wilkes discuss the POEM titled "High false positive rate in repeated, multimodal screening for cancers (PLCO)"
Download Episode 90 (mp3, 3.6MB)
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Episode 89: Treatment for insomnia
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Optimal treatment for persistent insomnia"
Download Episode 89 (mp3, 4.3MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 88: Conflicts of interest
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Pens and trinkets affect attitudes toward medications"
Download Episode 88 (mp3, 3.8MB)
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Episode 87: Diabetic analogues
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Insulin analogues of marginal, if any, benefit"
Download Episode 87 (mp3, 3MB)
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Episode 86: Nicotine replacement for those not ready to quit
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Nicotine replacement allows a few smokers to cut down despite initial unwillingness"
Download Episode 86 (mp3, 3.8MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 85: A polly pill for all
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Polypill improves CV risk markers, no data on outcomes (TIPS)"
Download Episode 85 (mp3, 3.6MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 84: Best time to start HIV treatment
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Early initation of antiretrovirals recommended in HIV disease"
Download Episode 84 (mp3, 3.2MB)
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Episode 83: Asthma and esophageal reflux
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Aggressive treatment of asymptomatic GERD does not improve asthma"
Download Episode 83 (mp3, 3.8MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 82: Endometrial polyps
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Incidental endometrial polyps rarely cancerous"
Download Episode 82 (mp3, 2.8MB)
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Episode 81: Religiosity and care at the end of life
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Religious coping associated with increased use of life-prolonging care near death"
Download Episode 81 (mp3, 2.5MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 80: Screening for PSA
Dr. Ebell and Dr. Wilkes discuss the POEM titled "PSA screening does not reduce mortality from prostate CA (PLCO)"
Download Episode 80 (mp3, 3.3MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 79: Vitamin D and osteoporosis
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Vitamin D, at high doses, prevents fractures"
Download Episode 79 (mp3, 3.7MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 78: BNP in heart failure
Dr. Ebell and Dr. Wilkes discuss the POEM titled "No difference in CHF outcomes with BNP-guided therapy"
Download Episode 78 (mp3, 4.3MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 77: Pneumococcal polysaccharide vaccine for adults
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Pneumococcal polysaccharide vaccine of questionable benefit for adults"
Download Episode 77 (mp3, 3.4MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 76: Intensive control of glucose in type II diabetes
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Intensive control of glucose does not improve T2DM outcomes (VADT)"
Download Episode 76 (mp3, 3.1MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 75: Safety of atypical antipsychotics
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Typical and atypical antipsychotics both increase risk of sudden cardiac death"
Download Episode 75 (mp3, 3.5MB)
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Episode 74: Generics for BP
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Generic and brand-name drugs equally effective for cardiovascular disease"
Download Episode 74 (mp3, 3.2MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 73: Exercise for preventing falls in elderly
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Exercise decreases falls in the elderly"
Download Episode 73 (mp3, 3.3MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 72: Steroids for migraine
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Dexamethasone may prevent headache recurrence after treatment of acute migraine"
Download Episode 72 (mp3, 2.9MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 71: Anxiety treatment for children and teens
Dr. Ebell and Dr. Wilkes discuss the POEM titled "CBT, sertraline, and combination effective for childhood anxiety disorders"
Download Episode 71 (mp3, 3.5MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 70: Antidepressants in teens
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Antidepressants only modestly effective for adolescent depression"
Download Episode 70 (mp3, 3.1MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 69: Statins for primary prevention
Dr. Ebell and Dr. Wilkes discuss the POEM titled "High dose statin reduces cardiac events in pts with high CRP (JUPITER)"
Download Episode 69 (mp3, 3.8MB)
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Episode 68: Usefulness of antidepressants
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Guideline: New antidepressants similarly effective (ACP)"
Download Episode 68 (mp3, 2.7MB)
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Episode 67: Preventative antibiotics for COPD
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Long-term erythromycin decreases COPD exacerbations"
Download Episode 67 (mp3, 3MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 66: Treatments for IBS
Dr. Ebell and Dr. Wilkes discuss two POEMs examining studies of treatments for IBS
Download Episode 66 (mp3, 2.6MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 65: PSA switching
Dr. Ebell and Dr. Wilkes discuss the POEM titled "USPSTF: No PSA screening in men 75 years and older"
Download Episode 65 (mp3, 3.6MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 64: ACE + ARB
Dr. Ebell and Dr. Wilkes discuss the POEM titled "ACE = ARB, but ACE + ARB worsens renal outcomes (ONTARGET)"
Download Episode 64 (mp3, 3.7MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 63: H. pylori and NSAID safety
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Pretreatment eradication of H. pylori improves NSAID safety"
Download Episode 63 (mp3, 3.7MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 62: Endocarditis prophylaxis
Dr. Ebell and Dr. Wilkes discuss the POEM titled "ACC/AHA: Fewer patients require prophylaxis for endocarditis"
Download Episode 62 (mp3, 3.3MB)
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Episode 61: Nuts, corn, and diverticular disease
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Nuts, corn, and popcorn not associated with risk of diverticular disease"
Download Episode 61 (mp3, 3.8MB)
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Episode 60: Diabetes and home monitoring
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Self-monitoring ineffective in patients with diabetes (ESMON)"
Download Episode 60 (mp3, 3.4MB)
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Episode 59: Homocysteine
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Homocysteine lowering not helpful in women at high risk for CVD"
Download Episode 59 (mp3, 3.6MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 58: Breast CA screening for high risk women
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Combined ultrasound + mammogram for high-risk women increases cancer yield"
Download Episode 58 (mp3, 4.7MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 57: Anxiety and insomnia
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Eszopiclone and escitalopram useful for anxiety and insomnia"
Download Episode 57 (mp3, 4.2MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 56: Quality of life after prostate cancer treatment
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Quality of life varies after different prostate cancer treatments"
Download Episode 56 (mp3, 3.5MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 55: Effectiveness of dementia treatments
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Dementia treatments minimally effective"
Download Episode 55 (mp3, 2.9MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 54: SSRIs and upper GI bleeding
Dr. Ebell and Dr. Wilkes discuss the POEM titled "SSRIs associated with upper GI bleeding"
Download Episode 54 (mp3, 3MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 53: Lung Age for smoking cessation
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Telling Lung AgeEsmokers their "lung age" increases quit rates"
Download Episode 53 (mp3, 3MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 52: CBT for depression
Dr. Ebell and Dr. Wilkes discuss the POEM titled "CBT+ alternative SSRI better than alternative SSRI alone in adolescent depression"
Download Episode 52 (mp3, 2.5MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 51: Screening for hepatitis C
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Screening for hepatitis C has minimal benefit (NNS = 4000)"
Download Episode 51 (mp3, 3.1MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 50: Antibiotics after I&D of skin abscess
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Antibiotics do not improve outcomes after I&D of skin abscess"
Download Episode 50 (mp3, 2.4MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 49: Surgery for lumbar spinal stenosis
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Surgery of some benefit for lumbar spinal stenosis"
Download Episode 49 (mp3, 3.2MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 48: Honey cough
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Single dose of honey effective for cough in kids"
Download Episode 48 (mp3, 2.8MB)
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Episode 47: Chewing gum and hospital discharge
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Chewing gum hastens bowel motility and shortens hospital stay after colorectal surgery"
Download Episode 47 (mp3, 3.2MB)
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Episode 46: Is there something else?
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Asking "Is there something else?" decreases patients' unmet concerns"
Download Episode 46 (mp3, 2.7MB)
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Episode 45: Atibiotics, steroids for acute sinusitis
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Antibiotics and nasal steroids of little/no benefit for acute sinusitis"
Download Episode 45 (mp3, 3.6MB)
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Episode 44: Drugs for kidney stones
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Alpha-blocker or nifedipine may help pass kidney stones"
Download Episode 44 (mp3, 3.1MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 43: HPV DNA screening
Dr. Ebell and Dr. Wilkes discuss the POEM titled "HPV DNA screening detects CIN3 and cancer earlier"
Download Episode 43 (mp3, 3.5MB)
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Episode 42: Lumbar supports
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Lumbar supports decrease symptoms but not work absence"
Download Episode 42 (mp3, 3.5MB)
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Episode 41: Oral contraceptives and cancer risk
Dr. Ebell and Dr. Wilkes discuss the POEM titled "OCs not associated with overall cancer risk"
Download Episode 41 (mp3, 3.1MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 40: Antibiotics for UR complications
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Antibiotics for URIs reduce complications (but not enough to matter)"
Download Episode 40 (mp3, 4.1MB)
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Episode 39: Bell's Palsy Treatments
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Prednisolone but not acyclovir effective for Bell's palsy"
Download Episode 39 (mp3, 2.9MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 38: Menopausal Symptoms
Dr. Ebell and Dr. Wilkes discuss the POEM titled ""
Download Episode 38 (mp3, 3.2MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 37: Early aggressive treatment of stroke
Dr. Ebell and Dr. Wilkes discuss the POEM titled "Aggressive early tx after TIA/minor stroke improves outcomes (EXPRESS)"
Download Episode 37 (mp3, 2.6MB)
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Episode 36: Minocycline and Stroke
Dr. Ebell and Dr. Wilkes discuss the InfoPOEM titled "Minocycline improves stroke outcomes"
Download Episode 36 (mp3, 3MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 35: Metformin for diabetics with HF
Dr. Ebell and Dr. Wilkes discuss the InfoPOEM titled "Metformin does not harm patients with HF and diabetes"
Download Episode 35 (mp3, 3MB)
Read the Related POEM synopsis. This will require an Essential Evidence Plus subscription.
Episode 34: Intensive lipid lowering
Dr. Ebell and Dr. Wilkes discuss the InfoPOEM titled "Intensive lipid lowering adds additional benefit"
Download Episode 34 (mp3, 3MB)
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Episode 33: Racial difference between hypertensives
Dr. Ebell and Dr. Wilkes discuss the InfoPOEM titled "Little information on racial differences between antihypertensives"
Download Episode 33 (mp3, 3.2MB)
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Episode 32: Pneumonia treatment w/ 3-5 days antibiotics
Dr. Ebell and Dr. Wilkes discuss the InfoPOEM titled "Pneumonia can be treated with 3 to 5 days of abx"
Download Episode 32 (mp3, 2.8MB)
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Episode 31: Bariatric Surgery
Dr. Ebell and Dr. Wilkes discuss the InfoPOEM titled "Bariatric surgery reduces all-cause mortality in morbidly obese"
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Episode 30: Chronic Constipation
Dr. Ebell and Dr. Wilkes discuss the InfoPOEM titled "PEG more effective than tegaserod for chronic constipation"
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Episode 29: PCOS
Dr. Ebell and Dr. Wilkes discuss the InfoPOEM titled "Clinical rule to diagnose PCOS more accurately"
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Episode 28: Leg Ulcers
Dr. Ebell and Dr. Wilkes discuss the InfoPOEM titled "Dressing choice unimportant for leg ulcers"
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Episode 27: Discussing Risk
Dr. Ebell and Dr. Wilkes discuss the InfoPOEM titled "Presenting risks in different ways affects perceptions"
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Episode 26: Surgery for Sciatica
Dr. Ebell and Dr. Wilkes discuss the InfoPOEM titled "Observation an option for patients with sciatica more than 6 weeks"
Download Episode 26 (mp3, 3.2MB)
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Episode 25: Folic Acid and Cancer
Dr. Ebell and Dr. Wilkes discuss the InfoPOEM titled "Folic acid does not reduce risk of colorectal adenomas"
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Episode 24: Zoldronic Acid and Osteoporosis
Dr. Ebell and Dr. Wilkes discuss the InfoPOEM titled "Zoledronic acid reduces fracture risk in osteoporosis, osteopenia with previous fracture"
Download Episode 24 (mp3, 3.3MB)
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Episode 23: Low dose aspirin
Dr. Ebell and Dr. Wilkes discuss the InfoPOEM titled "Aspirin dose >81mg daily not beneficial for secondary prevention of CVD"
Download Episode 23 (mp3, 2.7MB)
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Episode 22: Glitazones and CV risk
Dr. Ebell and Dr. Wilkes discuss the InfoPOEM titled "Rosiglitazone associated with increased risk of acute MI"
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Episode 21: Asthma
Dr. Ebell and Dr. Wilkes discuss the InfoPOEM titled "As needed steroid + beta-agonist works well in mild persistent asthma"
Download Episode 21 (mp3, 3.1MB)
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Episode 20: H Pylori
Dr. Ebell and Dr. Wilkes discuss the InfoPOEM titled "1 week = 2 week treatment for HP eradication".
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Episode 19: Capsule Endoscopy
Dr. Ebell and Dr. Wilkes discuss the InfoPOEM titled "Capsule endoscopy more sensitive than push enteroscopy".
Download Episode 19 (mp3, 2.7MB)
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Episode 18: Mammograms and False Positives
Dr. Ebell and Dr. Wilkes discuss the InfoPOEM titled "Sustained effects of false-positive mammogram results".
Download Episode 18 (mp3, 2.6MB)
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Episode 17: Diets
Dr. Ebell and Dr. Wilkes discuss the InfoPOEM titled "Atkins equally or more effective for weight loss in premenopausal women".
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Episode 16: PPIs and Hip Fractures
Dr. Ebell and Dr. Wilkes discuss the InfoPOEM titled "Long-term PPI use increases hip fracture risk".
Download Episode 16 (mp3, 3.3MB)
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Episode 15: Impact of Practice Guidelines
Dr. Ebell and Dr. Wilkes discuss the InfoPOEM titled "Increased use of COX-2 assoc with more overall GI bleeds".
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Episode 14: Acute Coronary Syndrome
Dr. Ebell and Dr. Wilkes discuss the InfoPOEM titled "Presence of risk factors doesn't predict acute coronary syndrome".
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Episode 13: Antibiotics and COPD
Dr. Ebell and Dr. Wilkes discuss the InfoPOEM titled "Procalcitonin test can reduce antibiotic use in COPD".
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Episode 12: Early oral treatment for CAP
Dr. Ebell and Dr. Wilkes discuss the InfoPOEM titled "Early switch to PO effective for severe CAP".
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Episode 11: Cohosh for vasomotor symptoms
Dr. Ebell and Dr. Wilkes discuss the InfoPOEM titled "Black cohosh ineffective for vasomotor symptoms".
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Episode 10: Folate for CVD risk
Dr. Ebell and Dr. Wilkes discuss the InfoPOEM titled "Folic acid supplementation does not reduce CVD risk nor mortality".
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Episode 9: Biomarkers and CAD
Dr. Ebell and Dr. Wilkes discuss the InfoPOEM titled "New biomarkers add little to current predictors for CAD".
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Episode 8: BNP and HF
Dr. Ebell and Dr. Wilkes discuss the InfoPOEM titled "BNP misleading in patients with a history of HF".
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Episode 7: Rosiglitazone for Diabetes
Dr. Ebell and Dr. Wilkes discuss the InfoPOEM titled "Rosiglitazone delays developing DM (DREAM)".
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Episode 6: Hereditary Breast Cancer Syndromes
Dr. Ebell and Dr. Wilkes discuss the InfoPOEM titled "Pedigree identifies hereditary breast cancer syndromes".
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Episode 5: Medications for Kidney Stones
Dr. Ebell and Dr. Wilkes discuss the InfoPOEM titled "Medications help passage of kidney stones".
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Episode 4: Antibiotics for Conjunctivitis
Dr. Ebell and Dr. Wilkes discuss the InfoPOEM titled "Antibiotics for conjunctivitis decreases symptom duration".
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Episode 3: Cardiovascular Risk of NSAIDs
Dr. Ebell and Dr. Wilkes discuss the InfoPOEM titled "Rofecoxib, diclofenac and indomethacin increase risk of CVD".
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Episode 2: PPIs and GI Complications
Dr. Ebell and Dr. Wilkes discuss the InfoPOEM titled "Omeprazole = pantoprazole for GI protection with NSAIDs".
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Episode 1: Antibiotic use for Otitis
Dr. Ebell and Dr. Wilkes discuss the InfoPOEM titled "Delayed prescription for AOM reduces unnecessary antibiotics".
Download Episode 1 (mp3, 4.5MB)
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